What is the approximate price of a box of acotinib/acabrutinib on the market?

Acalabrutinib (Acalabrutinib) is a new generation Bruton's tyrosine kinase (BTK) inhibitor, mainly used for the treatment of B-cell malignancies. BTK plays a central role in the B cell receptor signaling pathway and plays an important role in the development of B cell-related lymphoma and leukemia by regulating the proliferation, survival and migration of B cells. The emergence of acotinib provides new treatment options for patients with mantle cell lymphoma (MCL; non-Hodgkin lymphoma), chronic lymphocytic leukemia (CLL) and small lymphocytic lymphoma (SLL).

In terms of indications, acotinib is approved for the treatment of adult patients with mantle cell lymphoma who have received at least one prior therapy, and for the treatment of patients with chronic lymphocytic leukemia or small lymphocytic lymphoma. This type of disease often has a slow course but a high recurrence rate. Traditional chemotherapy and immunotherapy may not be able to completely control the disease. However, acotinib achieves effective intervention in the malignant proliferation of B cells by precisely inhibiting BTK signaling. It can delay disease progression, improve patients' quality of life, and shows a high remission rate.

As for the market price, the specifications of the original drug acotinib sold in China are100mg × 8 tablets × 7 plates, and the price per box is approximately RMB 20,000. Although it has been included in Class B medical insurance, reimbursement is limited to patients who meet the indications, which makes patients still face certain financial pressure. In overseas markets, the price of original drugs is higher. For example, the price of a single box of 100 mg × 60 tablets may exceed US$10,000. This reflects the high research and development costs and patent protection of innovative drugs in the international market. It is worth noting that generic drugs are already available overseas. For example, Laos Pharmaceutical’s 100 mg × 60 tablets are priced at more than 2,000 yuan. Although the price has been significantly reduced, it will still fluctuate with exchange rates and import policies.

Reference materials:https://www.calquence.com/