Are there any serious side effects of pemetinib/dalbertan targeted drugs?

Pemigatinib is an oral targeted drug targeting FGFR2 fusion genes or rearrangements. It is mainly used for patients with advanced or metastatic cholangiocarcinoma (CCA), especially those whose disease has progressed after conventional chemotherapy. As a targeted therapy drug, the advantage of pemetinib is that it precisely acts on tumor-related signaling pathways and reduces the extensive toxic and side effects of traditional chemotherapy, but it is not completely free of side effects. Understanding the possible adverse reactions of pemetinib is crucial for patients to use the drug safely and maintain their quality of life.

The side effects of pemetinib mainly involve the digestive system, skin, oral cavity, and electrolyte balance. Stomatitis is a common reaction, manifested by oral ulcers, pain, or redness and swelling of the mucous membranes, which can be relieved by keeping the mouth clean, using mild mouth rinses, and topical medications. Rashes, nail or skin pigment changes are also common side effects, usually mild to moderate, but may cause itching or discomfort in some patients and require the use of topical care and skin ointments. Diarrhea and mild dyspepsia may also occur and may be relieved by dietary modification and fluid management.

Elevated serum phosphate is a unique side effect of pemetinib, which is closely related to its inhibition of theFGFR pathway. High blood phosphorus may lead to abnormal calcium and phosphorus metabolism, affecting bone metabolism and cardiovascular health. Therefore, patients need to regularly monitor blood phosphorus and calcium levels during treatment. If serum phosphorus increases significantly, your doctor may recommend dietary intervention, medication adjustment, or temporary discontinuation of medication. Some patients may also experience mild fatigue, weakness or loss of appetite, but this can usually be alleviated through life management and nutritional support.

Overall, although the side effects of pemetinib exist, they are mostly controllable and manageable. Patients should strictly follow the doctor's instructions to take medications, regularly review blood and biochemical indicators, and cooperate with daily care measures, such as keeping the mouth and skin clean, eating a reasonable diet and getting enough rest.

Reference materials:https://go.drugbank.com/drugs/DB15102