What are the specific usage, side effects, and price of tobramycin inhalation solution?

For oral inhalation, the usual dosage for adults and children over 6 years of age is 1 disposable ampoule of tobramycin inhalation solution twice daily.

1. Preparation: First prepare the items. Place the top and bottom components of the atomizer, the nozzle and pipe with valve, the suction valve cover, etc. on a clean and dry surface, and wash your hands with soap and water.

2. Prepare the dose: Open the aluminum foil bag.

3. Separate ampoules: Gently pull the bottom label, separate 1 ampoule, and use immediately.

4. Twist the top: Hold the bottom tab on the BETHKIS ampoule with one hand and the top of the ampoule with the other hand while twisting the top. Do not squeeze the ampoule.

5. Hold the atomizer cup with one hand and rotate the top of the atomizer cup counterclockwise with the other hand.

6. Squeeze all the medicine in the ampoule into the atomizer cup, align the semicircle at the top of the atomizer cup with the atomizer cup outlet, and twist the top of the atomizer cup clockwise until it is tight.

7. Push the suction nozzle directly to the outlet of the atomizer cup, and push the inhalation valve cap directly downward to the top of the atomizer cup.

8. Connect one end of the pipeline to the air outlet of the compressor. The pipeline should fit tightly. Insert the compressor plug into the power socket. Hold the atomizer cup vertically and push the free end of the tube straight up and onto the air inlet at the bottom of the atomizer cup. Make sure the sprayer cup is upright.

9. Dose BETHKIS: Turn on the compressor and check the nozzle. Normally you will see a steady stream of mist coming from the mouthpiece. If stable aerosol is not seen, all pipe connections should be rechecked.

10. You can place your mouthpart between your teeth and on top of your tongue and breathe normally through your mouth only.

11. Breathe at the dose of BETHKIS for at least 15 minutes. When you hear the "spitting" sound from the nozzle for at least 1 minute and the atomizer cup is empty, you have received a full dose of the drug.

Things to note

1. The interval between each dose should be 12 hours as much as possible, and the interval between using tobramycin inhalation solution should not be less than 6 hours.

2. Use the handheld PARI LC PLUS reusable nebulizer equipped with a PARI Vios air compressor. Do not use any other nebulizer for treatment.

3. Do not mix or dilute tobramycin inhalation solution (BETHKIS) with Dowase alfa or other drugs in the nebulizer system.

4. Each treatment should take about 15 minutes, and should be inhaled while you are sitting or upright, and breathe normally through the nozzle of the atomizer.

5. If you forget to use BETHKIS, please take it as soon as possible if it is at least 6 hours before the next dose. Otherwise, wait for the next dose. Do not double your dose to make up for a missed dose.

6. After using tobramycin inhalation solution for 28 days, you should stop taking it and wait for 28 days. After stopping BETHKIS for 28 days, start taking BETHKIS again for 28 days. Even if you feel better, you must complete the full 28-day course of treatment. It is very important to maintain the 28-day dosing and 28-day off cycle.

1. Common side effects: Common adverse reactions that occur more frequently in BETHKIS patients are rales, increased erythrocyte sedimentation rate, decreased forced expiratory volume, dysphonia, and voice changes.

2. Serious adverse reactions: ototoxicity (hearing loss or tinnitus), nephrotoxicity, neuromuscular disease (worsening of muscle weakness), bronchospasm (shortness of breath with wheezing, coughing and chest tightness), etc.

drug prices

Tobi tobramycin inhalation solution 300mg/5ml, the reference price of the Turkish version produced and exported by Novartis in Switzerland is about 4963$. Patients who need to purchase medicine can obtain the medicine through regular overseas medical service institutions (such as Medical Companion Travel). For specific drug purchase procedures, please consult Medical Companion Travel Service.

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