非布索坦在国内批准上市了吗？

Has febuxostat been approved for marketing in China? Febuxostat is already on the market in the country. In 2013, febuxostat was launched in China.

Febuxostat tablets are a drug developed by Teijin Pharmaceutical of Japan for the treatment of gout. Febuxostat is very effective in reducing uric acid in the human body, and the effect is also fast. After taking Febuxostat, uric acid can be reduced to an ideal value. When using febuxostat to reduce uric acid in the human body, the dosage can be appropriately reduced according to the specific situation. However, it must be reduced under the guidance and supervision of a doctor, and it cannot be increased or decreased without permission, otherwise it will cause great harm to the body.

A phase III clinical trial compared the efficacy of this product (80 and 120 mg/d) with that of allopurinol (300 mg/d). A 1-year study of 760 patients showed that compared with the allopurinol group, more patients in the this product group achieved the main trial efficacy indicator - the sUA concentration measured in the last 3 months was less than 60mg/L (all subjects were gout patients, and the sUA concentration before the trial was above 80mg/L); during treatment After 52 weeks of treatment, this product failed to significantly reduce the area of tophi (tophi is an aggregate of urate crystals unique to gout), but the effect was more obvious in the high-dose group in the early stages of the trial; in each treatment group, patients with sUA concentrations reaching the target (<60mg/L) were less likely to have gout attacks again, and their tophi area was more significantly reduced.

Long-term use of febuxostat will have certain effects on the body's kidney and liver functions, and may cause symptoms such as rashes and even nausea. Therefore, when people take febuxostat, they should go to the hospital regularly to check the body's kidney and liver functions. This can ensure that the body is not greatly affected. If the liver and kidney functions are greatly harmed, other drugs can be replaced under the supervision of a doctor to reduce the harm to the body.