defiteli去哪里买？

Hepatic veno-occlusive disease (VOD) is one of the serious complications after hematopoietic stem cell transplantation (HSCT), and the mortality rate in patients with severe hepatic veno-occlusive disease (VOD) can be as high as 100%. Defiteli () is a single-stranded oligonucleotide mixture with anti-thrombotic and fibrinolytic effects. In recent years, multiple clinical research results have shown that defiteli is a safe and effective drug for preventing and treating VOD after HSCT.

On March 30, 2016, the FDA approved defibrotide (defiteli) for the treatment of adult and pediatric patients with hepatic veno-occlusive disease (VOD), also known as sinusoidal obstruction syndrome (SOS), and renal or pulmonary dysfunction following hematopoietic stem cell transplantation (HSCT).

Defiteli is an adenosine receptor agonist with multiple effects. The adenosine A1/A2 receptors of endothelial cells are involved in the regulation of endothelial cells and the response of endothelial cells to injury. Defiteli can act on these receptors to produce a variety of downstream effects.

defiteli can also reduce the expression of cell adhesion molecules on the surface of endothelial cells, thereby reducing the adhesion of leukocytes to vascular endothelial cells and reducing the inflammatory damage of endothelial cells. In addition, defiteli can also promote the release of prostaglandin I2 (PGI2) and prostaglandin E2 (PGE2), thereby causing blood vessel dilation, inhibiting platelet aggregation, and reducing ischemic damage. Studies have shown that defiteli can significantly increase the expression of thrombomodulin (TM) and tissue factor pathway inhibitors to produce anticoagulant effects.

Where to buy defiteli?

Defiteli () is not currently on the market in my country. The current price of defiteli on the market is around $22,000. Patients can go to the United States and other listed countries to buy it in person. Patients who are inconvenient to go abroad can also buy it through reliable overseas medical institutions in China.