注射爵士制药的去纤维钠的注意事项

Notes:

Bleeding: Defitelio may increase plasmin activity in vitro and may increase the risk of bleeding in patients with VOD after hematopoietic stem cell transplantation (HSCT). Do not initiate Defitelio treatment in patients with active bleeding. Monitor patients for signs of bleeding. If a patient develops symptoms of bleeding, discontinue use and provide treatment until bleeding stops. Concomitant use of defibrinated sodium and systemic anticoagulation or fibrinolytic therapy (not included for routine maintenance or reopening of central venous lines) may increase the risk of bleeding. Discontinue anticoagulants and fibrinolytics before defibrination therapy and consider delaying the use of defibrination until the effect of the anticoagulant has diminished.

Hypersensitivity reactions: Less than 2% of patients treated with defibrotide have experienced allergic reactions. These reactions include rash, urticaria, and angioedema. One case of an allergic reaction in a patient has been reported. Monitor patients for hypersensitivity reactions, especially those with past exposure. If a serious hypersensitivity reaction occurs, discontinue defibrotide sodium, treat according to standard of care, and monitor until symptoms resolve.

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