爱尔兰爵士制药的去纤维钠效果如何？

It is a biochemical drug derived from a mixture of single-stranded deoxyoligonucleotides. It mainly acts on endothelial cells and produces a variety of biological effects. Clinical research is mainly carried out around the indications of cardiovascular dysfunction. Clinical experiments have proven that defibrotide can effectively prevent and treat hepatic veno-occlusive disease (VOD).

Defibrotide sodium was granted Priority Review and Orphan Drug designation. The approval was based on a Phase 2 trial of 75 patients, a Phase 3 trial of 102 patients, and an expansion trial of an additional 351 patients. All patients in the trial were diagnosed with hepatic veno-occlusive disease and associated renal or pulmonary dysfunction after HSCT.

In the phase 2 trial, 44% of patients survived 100 days after transplantation, compared with 38% in the phase 3 trial and 45% in the expanded trial, and the FDA noted in a report that the expected 100-day survival rate for patients with severe hepatic veno-occlusive disease who were not treated with defibrotide was 21%-31%.

Data on the drug's safety are based on 176 patients. The most common adverse reactions include hypotension, diarrhea, vomiting, nausea, and epistaxis. The most common serious adverse reactions included hypotension (11%) and alveolar hemorrhage (7%). The approval of defibrotide sodium greatly meets the treatment needs of transplant patients suffering from this rare fatal complication.

Jazz Pharmaceuticals was founded in 2003 and is headquartered in Dublin, Ireland, with 885 full-time employees. It is a commercial-stage biopharmaceutical company engaged in the identification, development and commercialization of pharmaceutical products. According to Medical Companion Travel, the 200mg specification is around 21,600. Since the exchange rate is floating and the price is not fixed, if you want to buy defibrinated sodium but don’t want to go out, you can contact domestic and overseas medical institutions (Medical Travel) to help you buy defibrinated sodium, direct mail from overseas, 100% authentic.