爱尔兰爵士制药的defiteli效果怎么样？

Defibrotide sodium (defibrinoside) from Irish Jazz Pharmaceuticals is an adenosine receptor agonist with multiple effects. The adenosine A1/A2 receptors of endothelial cells are involved in the regulation of endothelial cells and the response of endothelial cells to injury, and can treat hepatic veno-occlusive disease (VOD).

How effective is Irish Jazz Pharmaceuticals' defiteli?

In the pilot study, 528 patients diagnosed with VOD symptoms after HSCT were included in 3 studies to evaluate the effectiveness of Irish Jazz Pharmaceuticals' defiteli defibrinoside (defibrinosodium). These patients were also accompanied by liver or kidney function abnormalities. The evaluation index is the overall survival rate 100 days after HSCT.

The results showed that the survival rate of patients who received defibrotide treatment after 100 days was 38% to 45%; while data analysis found that the survival rate of HSCT patients who were expected to receive only supportive care or other drug intervention after 100 days was only 21% to 31%. Using defiteli defibrotide from Sir Irish Pharmaceuticals can effectively improve the survival rate of patients. In clinical trials, heparin is usually used to prevent diseases such as hepatic veno-occlusion, which also greatly increases the patient's risk of bleeding. However, defibrotide alone or in combination with heparin has a low incidence of side effects, good safety, and has achieved good VOD prevention effects. Defibrinoside (Defibrotide Sodium) from Sir Irish Pharmaceuticals is also currently recognized as a relatively effective drug in the treatment of hepatic veno-occlusive disease (VOD).

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