爱尔兰爵士制药的defiteli适用于什么病症？

What diseases is Sir Irish Pharmaceuticals suitable for? Irish Jazz Pharmaceuticals' defiteli is a single-stranded oligonucleotide mixture with anti-thrombotic and fibrinolytic effects. It is suitable for the treatment of adult and pediatric patients with hepatic veno-occlusive disease (VOD), also known as sinusoidal obstruction syndrome (SOS), and renal or pulmonary dysfunction after hematopoietic stem cell transplantation (HSCT).

Defiteli is an adenosine receptor agonist with multiple effects. The adenosine A1/A2 receptors of endothelial cells are involved in the regulation of endothelial cells and the response of endothelial cells to injury. Defiteli can act on these receptors to produce a variety of downstream effects. Defibrotide can also reduce the expression of cell adhesion molecules on the surface of endothelial cells, thereby reducing the adhesion of leukocytes to vascular endothelial cells and reducing the inflammatory damage of endothelial cells. In addition, defibrotide can also promote the release of prostaglandin I2 (PGI2) and prostaglandin E2 (PGE2), thereby causing blood vessel dilation, inhibiting platelet aggregation, and reducing ischemic damage. Studies have shown that defibrotide can significantly increase the expression of thrombin regulatory protein (TM) and tissue factor pathway inhibitors to produce anticoagulant effects.

Defibrinoside () should be used under the guidance of a doctor. The recommended dose of defiteli for adult and pediatric patients is 6.25 mg/kg given every 6 hours as a 2-hour intravenous infusion.

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