使用去纤苷需要注意什么？去纤苷应该如何使用呢？

去纤苷具有抗血栓、抗炎症反应和促纤维蛋白溶解的特性，是一种单链的多聚脱氧核糖核酸的钠盐。 Defibrotide is indicated for the treatment of adult and pediatric patients with hepatic veno-occlusive disease (VOD), also known as sinusoidal obstruction syndrome (SOS), and renal or pulmonary dysfunction after hematopoietic stem cell transplantation (HSCT). What should I pay attention to when using it? How should defibrinoside be used?

给药前，确证患者没有经受临床上意义的出血和是对不超过一种血管加压素血流动力学上稳定。

使用去纤苷治疗可能会导致出血，有活动性出血患者不要使用该药品治疗。 Monitor patients for signs of bleeding.如患者使用去纤苷发生出血，则应停止使用该药品。应当立即诊断患病原因，并提供支持性医护直至出血停止。

Treatment with defibrotide may result in hypersensitivity reactions. If a severe or life-threatening allergic reaction occurs while receiving drug therapy, discontinue defibrotide and treat with standard medical care until signs and symptoms resolve.

Defibrinoside usage and dosage

成年和儿童患者的推荐剂量为：6.25 mg/kg，每6小时给予作为一个2小时静脉输注。 The dose should be based on the patient's baseline weight, which is defined as the patient's weight before the HSCT (hematopoietic stem cell transplant) preparation protocol.

Defibrotide was administered for a minimum of 21 days. If signs and symptoms of hepatic veno-occlusive disease do not resolve after 21 days, continue treatment with defibrotide until resolution of hepatic veno-occlusive disease or up to 60 days.

The above is an introduction to the precautions, usage and dosage of Defibrotide. If patients want to know more drug information about this drug, they can consult the medical companion travel service.

Note: The above information comes from the Internet and is compiled and edited by Medical Companion Travel (please correct me if there are any errors or omissions). It is only to provide information on the latest drugs on the market in the world and help Chinese patients understand the latest international new drug trends. It is only for internal discussion among medical staff and does not serve as any basis for medication. For specific medication guidelines, please consult the attending physician.

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