【用法用量】去纤苷应该怎么使用？一般多久会见效

Defibrotide is a single-stranded oligonucleotide mixture that has anti-thrombotic and fibrinolytic effects. The drug was approved for marketing in the United States in 2016. It is a new drug for the treatment of hepatic veno-occlusive disease (HVOD). It has the effects of anticoagulation, promoting fibrinolysis, and promoting blood vessel formation. How should it be used? How long does it usually take for it to take effect?

Defibrinoside usage and dosage

The recommended dose for treatment of adult and pediatric patients with defibrotide is 6.25 mg/kg as an intravenous infusion every 6 hours. Defibrotide was administered for a minimum of 21 days. If the patient's signs and symptoms of hepatic veno-occlusive disease do not resolve after 21 days of treatment with this drug, continue defibrotide treatment until resolution of hepatic veno-occlusive disease or for a maximum of 60 days. Patients should note that the recommended dose of defibrotide treatment should be determined based on the patient's baseline weight, which is the patient's weight before preparation for HSCT (hematopoietic stem cell transplantation). In addition, patients should dilute defibrotide before infusion, and defibrotide should not be co-administered with other intravenous drugs in the same intravenous line. Patients should not increase or decrease the dosage of medication without authorization to avoid other adverse reactions and affect their condition.

Since each patient's condition, personal constitution, and tolerance to drugs are different, the effective time and therapeutic effects after receiving defibrotide treatment will also be different. The effective time after treatment with defibrotide is mainly determined by the patient's disease stage and personal constitution, and there is no accurate time point. When patients receive defibrotide treatment, they strictly follow the doctor's diagnosis and treatment recommendations and believe that they will have good results soon.

Note: The above information comes from the Internet and is compiled and edited by Medical Companion Travel (please correct me if there are any errors or omissions). It is only to provide information on the latest drugs on the market in the world and help Chinese patients understand the latest international new drug trends. It is only for internal discussion among medical staff and does not serve as any basis for medication. For specific medication guidelines, please consult the attending physician.

  Recommended hot articles: