去纤苷要用多长时间,副作用有什么？

(Defitelio) has received "orphan drug" designation and "priority review" status, and is approved for the treatment of hepatic vein obstruction caused by hematopoietic stem cell transplantation in adults and children. It is the first drug approved in the United States to treat severe hepatic vein obstruction. Hepatic vein occlusion is a rare but fatal condition that commonly occurs in blood cancer patients who have received high-dose chemotherapy and hematopoietic stem cell transplantation. Symptoms of hepatic vein occlusion are blockage of blood vessels in the liver, resulting in reduced blood exchange and swelling in the liver, which can cause liver damage and possibly kidney and lung failure. About 2% of people who receive hematopoietic stem cell transplants will develop such complications, and 80% of them are fatal. So, how long should defibrinoside be used and what are the side effects?

How long does defibrination take?

Defitelio should be used under the guidance of a doctor. The recommended dose of defibrotide for adult and pediatric patients is 6.25 mg/kg given every 6 hours as a 2-hour intravenous infusion. The dose should be based on the patient's baseline weight, which is defined as the patient's weight before the HSCT preparation protocol. Defibrotide was administered for a minimum of 21 days. If signs and symptoms of hepatic VOD have not resolved after 21 days, continue defibrotide until resolution of VOD or up to a maximum of 60 days.

What are the side effects of defibrotide?

For hypotension, nausea, vomiting, allergic reactions, nose bleeding, diarrhea, etc. Here, the editor of Medical Companion Travel has something to say. During the treatment with defibrotide, the editor recommends that patients strictly abide by the doctor's instructions and take the correct medication. Different drugs have different dosages and cycles. The specific dosage and cycle should be formulated by the doctor for you.

Note: The above information comes from the Internet and is compiled and edited by Medical Companion Travel (please correct me if there are any errors or omissions). It is only to provide information on the latest drugs on the market in the world and help Chinese patients understand the latest international new drug trends. It is only for internal discussion among medical staff and does not serve as any basis for medication. For specific medication guidelines, please consult the attending physician.

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