去纤苷副作用该如何处理？

Defiteli (defiteli) is a mixture of sodium salts of single-stranded deoxyoligonucleotides produced by controlled depolymerization of porcine intestinal mucosal genomic DNA. Its mechanism of action is complex and has not yet been fully elucidated.

Defibrotide (defiteli) is the first drug approved by the U.S. FDA for the treatment of severe hepatic veno-occlusive disease. It is used for adult or pediatric patients with hepatic venous obstruction (VOD) and renal or lung function abnormalities after receiving blood or bone marrow hematopoietic stem cell transplantation (HSCT). The drug has also received "orphan drug" designation.

Defibrotide is well tolerated, and the most common side effects (incidence ≥10% and independent causal relationship) with treatment with defibrotide (defiteli) are hypotension, diarrhea, vomiting, nausea, and epistaxis. The incidence of grade 3-4 reactions related to defibrotide was 7%, mainly hypotension, pulmonary and gastrointestinal bleeding, and abdominal cramps. Only 4% of patients discontinued treatment due to side effects. This means that the side effects of defibrotide are usually mild.

How should we deal with the possible side effects of defibrotide?

In order to minimize side effects in daily life, patients must first strictly follow the doctor's instructions during medication, use medication under the guidance of a doctor, and understand the interactions between different drugs. In vitro defibrination (defiteli) increases the activity of plasmin, and phlegm may increase the risk of bleeding after hematopoietic stem cell transplantation (HSCT) in patients with VOD. Do not initiate defibrotide in patients with active bleeding. In addition, in terms of diet, focus on light meals and pay attention to balanced nutrition; maintain adequate sleep and enhance the body's resistance. If the patient feels that the side effects are strong and unbearable during the medication, he should stop taking the medication and seek medical treatment in time.

The above are the side effects of defibrotide and simple treatment methods. I hope it will be helpful to you.