Enrig Chinese manual

Chinese instruction manual

Mechanism of action:

DFS has pharmacological effects such as antifungal effects (such as Mucor mold that grows in iron-rich environments), anti-cell proliferation, anti-malarial effects, anti-oxidative stress damage, and anti-cytotoxicity-induced apoptosis.

1.DFS and fungal infection

Iron is a substance that fungi rely on for survival, and it plays a very important role in the growth and toxicity of fungi. The antifungal effect of iron chelators may lie in their removal of iron necessary for fungal growth, thereby achieving the purpose of treating fungal infections.

2.DFS and cell proliferation

Iron plays a very important role in the process of cell proliferation, and iron chelators may have anti-cell proliferation properties. This suggests that iron chelators may become a new type of anti-cancer agent for the treatment of tumors.

Indications:

It is used to treat chronic iron overload in beta-thalassemia patients older than 6 years old due to frequent blood transfusions (monthly administration of concentrated red blood cells ≥ 7 mL/kg). For iron overload caused by children under 6 years old and other transfusion-dependent diseases, the safety and effectiveness data of Enrig Chinese patients are limited, and it is recommended to use it with caution based on the specific conditions of the patient.

Usage and dosage:

Starting dose:

The recommended starting daily dose of deferasirox is 20 mg/kg.

For patients who receive monthly transfusions of more than 14 mL/kg of packed red blood cells (i.e., more than 4 units/month in adults) and who need to reduce excess iron exposure, a starting dose of 30 mg/kg/day may be considered.

For patients who receive monthly transfusions of less than 7 mL/kg of packed red blood cells (i.e., less than 2 units/month in adults) and who need to maintain body iron balance, a starting dose of 10 mg/kg/day may be considered.

In patients who have already responded well to deferoxamine therapy, an initial dose of Enriga equivalent to half the deferoxamine dose may be considered. (For example, a patient receiving deferoxamine 40 mg/kg/day, 5 days per week, or equivalent, may start at 20 mg/kg if switched to Enriga.)

How to take:

Deferasirox should be taken once daily on an empty stomach, at least 30 minutes before a meal, preferably at the same time each day. Tablets should not be chewed or swallowed whole.

Deferasirox () should not be taken with aluminum-containing antacids, and the dose (mg/kg) needs to be calculated and rounded to the nearest whole tablet. Completely dissolve the tablets in water, apple juice or orange juice (100-200mL) by stirring until a clear suspension is obtained and then drink it. The remaining medicine must be added with a small amount of water, apple juice or orange juice and mixed well before taking. Not recommended for dissolution in carbonated drinks or milk as it can cause foaming and slow dispersion.