恩瑞格是什么时候上市的呢？

It is a ligand with three protrusions. Although the affinity of Enrige to zinc and copper is very low, the concentrations of these trace metals in the serum still decreased to varying degrees after administration. The tolerability and safety of Enrige are relatively good among similar drugs. Therefore, patients can also take it for a long time, but it is best to consult a doctor first and use it under the guidance of a doctor to avoid adverse reactions. Today let’s take a look at when Enrig was listed?

Deferasirox was approved by the FDA in November 2005 for use in patients 2 years and older with chronic iron overload caused by blood transfusions. In December 2012, Deferasirox was approved by the European Commission for the treatment of chronic iron overload in patients aged 10 years and above with non-transfusion-dependent thalassemia (NTDT) syndrome who require chelation therapy due to contraindications or insufficiency of deferoxamine mesylate therapy. On January 23, 2013, the FDA approved a new indication for Deferasirox for the treatment of chronic iron overload in patients with non-transfusion-dependent thalassemia (NTDT) aged 10 years and above. Deferasirox needs to be used in sufficient quantity and for a sufficient period of time as prescribed by your doctor. In China, only the original Novartis Pharmaceuticals' Enrig dispersible tablets (trade name: Enrig) ​​were launched in June 2010, and only Jiangsu Aosaikang Pharmaceutical is applying for a domestic imitation. Before the disease is completely controlled, your symptoms may be relieved, but do not reduce the dosage or stop taking the medicine easily. 

Usage and dosage of Deferasirox: The recommended starting daily dose of Deferasirox is 20mg/kg. For patients who receive monthly transfusions of more than 14 mL/kg of packed red blood cells (i.e., more than 4 units/month in adults) and who need to reduce excess iron exposure, a starting dose of 30 mg/kg/day may be considered. For patients who receive monthly transfusions of less than 7 mL/kg of packed red blood cells (i.e., less than 2 units/month in adults) and who need to maintain body iron balance, a starting dose of 10 mg/kg/day may be considered.

Enriga should be taken once a day on an empty stomach, at least 30 minutes before a meal, preferably at the same time each day. Tablets should not be chewed or swallowed whole. Enrige should not be taken with aluminum-containing antacids, and the dosage (mg/kg) needs to be calculated and rounded to the nearest whole tablet. Completely dissolve the tablets in water, apple juice or orange juice (100-200mL) by stirring until a clear suspension is obtained and then drink it. The remaining medicine must be added with a small amount of water, apple juice or orange juice and mixed well before taking. Not recommended for dissolution in carbonated drinks or milk as it can cause foaming and slow dispersion.

The above is the content of the listing, I hope it can help you!