Desirox如何使用呢？

Approved for marketing in China in 2010, Desirox can be used for patients with iron accumulation due to long-term blood transfusion (such as thalassemia or other rare anemias). It is suitable for children over two years old and adults.

So, how to use Desirox?

How to use Desirox: The recommended starting daily dose is 20 mg/kg. For patients who receive monthly transfusions of more than 14 mL/kg of packed red blood cells (ie, more than 4 units/month in adults) and who need to reduce excess iron exposure, a starting dose of 30 mg/kg/day may be considered.

For patients who receive monthly transfusions of less than 7 mL/kg of packed red blood cells (i.e., less than 2 units/month in adults) and who need to maintain body iron balance, a starting dose of 10 mg/kg/day may be considered. In patients who have already responded well to deferoxamine therapy, an initial dose equivalent to half the deferoxamine dose may be considered. Take it on an empty stomach at least 30 minutes before meals, once a day, preferably at the same time every day.

Dose adjustment of Desirox:

Myelosuppression: Interrupt treatment;

Once the cause of the cytopenia is identified, it may be restarted;

Disabled if platelet count <50,000/mm3;

Cutaneous Toxicity: Rash (Severe): Interrupt treatment; may be reintroduced at lower doses (with future dose escalations) and oral corticosteroids for a short period of time.

Serious skin reactions (Stevens-Johnson syndrome, toxic epidermal necrolysis, erythema multiforme): Stop and evaluate.

Gastrointestinal: Discontinue treatment for suspected gastrointestinal ulceration or bleeding. Hearing loss or visual impairment: Consider dose reduction or treatment interruption.

Common adverse reactions of Desirox: diarrhea, vomiting, headache, abdominal pain, fever, rash, increased serum creatinine, etc.

Other adverse reactions: increased liver enzymes, cough, throat inflammation, urticaria.