铁质积聚治疗用药地拉罗司上市了吗？

(Enrig) effectively treats iron overload caused by transfusion-dependent rare blood diseases such as aplastic anemia, myelodysplastic syndrome, and thalassemia, helping patients with iron overload delay disease progression and prolong survival time. Today we will learn more about the iron accumulation treatment drug Deferasirox on the market?

In 2010, Deferasirox (Enrige) was approved for marketing in China for the treatment of chronic iron overload caused by frequent blood transfusions (monthly administration of concentrated red blood cells ≥ 7 mL/kg) in beta-thalassemia patients older than 6 years old. For children under 6 years old and iron overload caused by other transfusion-dependent diseases, the safety and effectiveness data of Deferasirox in Chinese patients are limited, and it is recommended to use it with caution based on the specific situation of the patient.

A multicenter, prospective clinical trial was conducted to evaluate the safety and efficacy of deferasirox in patients with low- or intermediate-risk-1 myelodysplastic syndrome (MDS). The study selected patients with serum ferritin ≥1000 μg/L, transfusion dependence and red blood cell transfusions ≥20U to be included. The starting dose of deferasirox (Enrige) is 20 mg/kg/d, which can be adjusted up to 40 mg/kg/d. A total of 176 patients were enrolled in the study, of whom 173 received treatment. 53% of patients completed 12 months of treatment (n = 91) with a 23% decrease in mean serum ferritin, 36.7% completed 2 years of treatment (N = 49), and 36.5% completed 3 years of treatment (N = 33).

The study found that the reduction of serum ferritin was significantly positively correlated with the improvement of ALT (P <0.001). Baseline labile plasma iron (LPI) was elevated in 68 patients (39.3%). After 13 weeks, all patients with abnormal baseline LPI levels returned to normal.

How to take:

Deferasirox should be taken once daily on an empty stomach, at least 30 minutes before a meal, preferably at the same time each day. Tablets should not be chewed or swallowed whole.

Deferasirox (Enreg) should not be taken with aluminum-containing antacids, and the dose (mg/kg) needs to be calculated and rounded to the nearest whole tablet.

Completely dissolve the tablets in water, apple juice or orange juice (100-200mL) by stirring until a clear suspension is obtained and then drink it. The remaining medicine must be added with a small amount of water, apple juice or orange juice and mixed well before taking. Not recommended for dissolution in carbonated drinks or milk as it can cause foaming and slow dispersion.

The above is the content of (Enrige) listing, I hope it can help you!

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