kaftrio(Trikafta)的用法用量:用药指南,剂量调整,特殊人群用药,用药注意事项

‌Morning dose‌

Take orally 2 tablets (containing elecarpol 100mg/tezakafor 50mg/ivacaftor 75mg) once in the morning.

‌Evening dose‌

Take 1 tablet (containing ivacaftor 150mg) orally once in the evening.

2. ‌Medication Notes

Gene Testing

If the genotype is unknown, it is necessary to confirm that the patient carries at least one F508del mutation or a responsive mutation supported by in vitro data through FDA-approved cystic fibrosis (CF) mutation testing.

Length of dosing interval

The interval between two doses should be approximately 12 hours.

Precautions for taking together

kaftrio (Trikafta) should be taken with fatty foods.

2. Children's dosage ‌

1. ‌2 years old to <6 years old‌

2 years old to <6 years old‌, ‌weight <14kg‌

Take orally 1 packet of granules (containing 80 mg of elecarpol/40 mg of terzacafort/60 mg of ivacaftor) once in the morning.

Take 1 packet of granules (containing ivacaftor 59.5mg) orally once in the evening.

‌2 years old to <6 years old‌, weight ≥14kg‌

Take orally 1 packet of granules (containing elecarpol 100mg/tezakafor 50mg/ivacaftor 75mg) once in the morning.

Take 1 packet of granules (containing ivacaftor 75mg) orally once in the evening.

2. ‌6 years old to <12 years old‌

‌6 years old to <12 years old, weight <30kg‌

Take orally 2 tablets (containing elecarpol 50mg/Terzacafort 25mg/Ivacaftor 37.5mg) once in the morning.

Take 1 tablet (containing ivacaftor 75mg) orally once in the evening.

‌6 to <12 years old, weight ≥30kg‌

Take orally 2 tablets (containing elecarpol 100mg/tezakafor 50mg/ivacaftor 75mg) once in the morning.

Take 1 tablet (containing ivacaftor 150mg) orally once in the evening.

3. ‌≥12 years old‌

Same as adult dosage regimen.

4. Medication precautions

Gene testing

If the genotype is unknown, it is necessary to confirm that the patient carries at least one F508del mutation or a responsive mutation supported by in vitro data through FDA-approved cystic fibrosis (CF) mutation testing.

Dosing interval

The interval between two doses of kaftrio (Trikafta) is about 12 hours.

Notes on the same server

kaftrio (Trikafta) granules need to be mixed with soft food or liquid before taking.

3. Dose adjustment

1. Renal function adjustment‌

Mild to moderate renal insufficiency (CrCl≥30mL/min/1.73m²): No dose adjustment is required.

‌Severe renal insufficiency (CrCl<30mL/min/1.73m²) or end-stage renal disease (ESRD): ‌Use with caution (data limited).

2. ‌Liver function adjustment‌

‌Mild liver injury (Child-Pugh A grade): ‌No adjustment required.

‌Moderate hepatic impairment (Child-Pugh Class B): Use with caution. ‌

3. ‌2 years old to <6 years old‌

(1) 2 years old to <6 years old‌, ‌weight <14kg‌

Days 1-3: Take 1 packet of granules (elacapor 80mg/tezakafor 40mg/ivacaftor 60mg) orally in the morning.

Day 4: Stop taking medication.

Day 5-6: Take 1 packet of granules orally in the morning.

Day 7: Stop taking medication.

‌Cycle this weekly regimen, and do not take evening ivacaftor granules every day‌.

(2) 2 years old to <6 years old‌, weight ≥14kg‌

Same plan, switch to granules containing elecarpol 100mg/tezakafort 50mg/ivacaftor 75mg.

‌4. 6 years old to <12 years old‌

‌ (1) 6 years old to <12 years old‌, weight <30kg‌

Day 1: Orally take 2 tablets in the morning (elicapol 50mg/Tezakafor 25mg/Ivacaftor 37.5mg).

Day 2: Orally take 1 tablet (same ingredients as above) in the morning.

‌Cycle this alternating regimen, and daily evening ivacaftor tablets are prohibited.

‌ (2) 6 years old to <12 years old‌, weight ≥30kg‌

Same plan, but use tablets containing elecarpol 100mg/tezakafort 50mg/ivacaftor 75mg.

Warm reminder‌

Patients with moderate liver damage should only use it when their medical needs are clear and the benefits outweigh the risks, and liver function needs to be closely monitored.