非达霉素(Dificid)会引起哪些副作用

Fidaxomicin, also known as Dificid, and its generic name is fidaxomicin, is a macrolide antibacterial drug specially used to treat Clostridium difficile-related diarrhea. It is suitable for adults and children over 6 months old. This article will introduce in detail the possible side effects of fidaxomicin and medication precautions for special groups.

What side effects will fidaxomicin (Dificid) cause?

Common gastrointestinal reactions

1. The incidence of nausea is 11%, usually mild.

2. The incidence of vomiting is 7%, and most patients can tolerate it.

3. The incidence rate of abdominal pain is 6%. It is recommended to take it after meals for relief.

4. The incidence of gastrointestinal bleeding is 4% and requires close observation.

Abnormalities of the blood system

1. The incidence of anemia is 2%. It is recommended to monitor blood routine regularly.

2. The incidence of neutropenia is 2%, and signs of infection need to be paid attention to.

3. Thrombocytopenia is occasionally reported, so attention should be paid to bleeding tendency.

4. If you have fever or other symptoms of infection, you should seek medical treatment promptly.

Abnormal liver function indicators

1. The incidence of elevated transaminases in children is 5%.

2. Alkaline phosphatase elevation occasionally occurs. It is recommended to monitor liver function indicators during treatment.

3. Severe liver damage is rare but still requires vigilance.

Allergic reaction

1. The incidence rate of rash is 5%, including a variety of rash types, and itching symptoms may appear along with the rash.

2. Although angioedema is rare, it requires urgent treatment.

3. Severe allergic reactions such as difficulty breathing require immediate medical attention.

Other common adverse reactions

Fever occurs in 13% of children, constipation occurs in 5%, headache symptoms occasionally occur, usually temporary, and fatigue may occur.

Serious adverse reactions

Including severe allergic reactions, serious abnormalities in the blood system, superinfection with Clostridium difficile, etc. Any serious side effects should be treated with a doctor in time.

What are the special medication groups for fidaxomicin (Dificid)

Usage in pediatric patients

1. The safety of infants under 6 months of age has not been established.

2. The dose needs to be accurately calculated based on body weight from 6 months to 18 years old.

3. Children who can swallow tablets can use tablet form, while those who cannot swallow tablets need to use oral suspension.

Dose for elderly patients

1. The elderly usually do not need to adjust the dosage of the drug

2. The plasma concentration of elderly patients may increase slightly, and changes in liver and kidney function need to be monitored.

3. Pay attention to the interaction between the drug and other concomitant medications.

Patients with hepatic insufficiency

1. Patients with mild to severe hepatic insufficiency do not need to adjust the dose.

2. Timely evaluation should be carried out when liver function deteriorates

Patients with renal insufficiency

It is safe to use in patients with end-stage renal disease. Patients with different degrees of renal insufficiency do not need to adjust the dosage.

Pregnant and lactating women

1. The use data during pregnancy are limited, and the pros and cons need to be weighed

2. Animal experiments show that there is no risk of embryo-fetal toxicity, and the safety data for use during lactation are insufficient. It is recommended to suspend breastfeeding during medication.

Patients with allergies

1. Those allergic to macrolide drugs should use with caution.

2. Ask about drug allergy history in detail before use, and closely monitor allergic reactions during medication.