美沙拉秦(Salofalk)是治疗什么疾病的

Mesalazine (Salofalk) has been approved in many countries and regions around the world, and its safety and efficacy are continuously monitored.

What diseases does Mesalazine (Salofalk) treat?

1. Ulcerative colitis

It is suitable for mild to moderate ulcerative colitis in adults and children aged 6 years and above.

2. Crohn's disease

Applicable to Crohn's ileitis and colitis in adults and adolescents aged 12 years and above. It is also used for acute phase treatment and remission maintenance to reduce disease recurrence.

Efficacy and role of mesalazine (Salofalk)

The core effect of mesalazine (Salofalk) lies in its local anti-inflammatory effect, which directly acts on the intestinal mucosa and reduces the inflammatory response through multiple mechanisms.

Mesalazine acts locally on the intestinal mucosa, inhibits the synthesis of inflammatory mediators (such as leukotrienes, prostaglandins), and has an oxygen free radical scavenging effect. The specific mechanism is not yet fully understood.

The pictures are from public channels (such as the official website of the FDA, the official website of the original drug manufacturer, etc.) and are for reference only.

Mesalazine (Salofalk) Usage and Dosage

1. Adults and the elderly

(1) Acute phase treatment: 1.5 grams per day for ulcerative colitis; 3-4.5 grams per day for Crohn's disease.

(2) Maintenance treatment: 1.5 grams per day for ulcerative colitis; 1.5-3 grams per day for Crohn's disease.

2. Pediatric patients

The dose is calculated based on body weight, usually 30-50 mg/kg per day in the acute phase and 15-30 mg/kg per day in the maintenance phase. The maximum daily dose does not exceed the upper limit for adults.

3. How to take the medicine

The tablets should be swallowed in one gulp. Do not chew or crush them before taking them orally. They should be taken with enough water. For best absorption, it is recommended to take it at least 1 hour before a meal.

Common and serious adverse reactions of mesalazine (Salofalk)

1. Common (≥1%-<10%)

Headache, abdominal pain, diarrhea, nausea, vomiting, indigestion, bloating, exacerbation of ulcerative colitis, and rash (including itching, urticaria).

2. Rare (<1%)

Fever, allergic reaction, dizziness, paresthesia, peripheral neuropathy, acute pancreatitis, pancolitis, neonatal diarrhea, hepatitis, elevated liver enzymes, intrabiliary cholestasis, elevated bilirubin. Arthralgia, myalgia, myositis, pericarditis, myocarditis, pericardial effusion.

Thrombocytopenia, aplastic anemia, hemolytic anemia, reversible spermatozoa. Allergic pulmonary reaction, dyspnea, cough, bronchospasm, pleural effusion, alveolitis, pulmonary eosinophilia, pulmonary infiltrates, pneumonia.

3. Rare (<0.1%)

Photosensitivity reaction (especially in patients with existing skin diseases).

4. Very rare (<0.01%)

Cholestatic hepatitis.

5. Unknown frequency

Kidney stones, severe skin reactions (DRESS, SJS, TEN), idiopathic intracranial hypertension.