【阿瑞匹坦药品百科】想真正了解Aprepitant看这里

Aprepitant has a unique mode of action as it is a selective and high-affinity antagonist of the human substance P Neurokinin1 (NK1) receptor. Let’s learn about antagonists next.

【Indications】

Aprepitant is indicated for the prevention of acute and delayed nausea and vomiting during initial and repeated treatment with highly emetogenic antineoplastic chemotherapy when administered in combination with other antiemetics.

  【Usage and Dosage】

Aprepitant is a three-day intervention and includes a course of treatment with a corticosteroid and a 5-HT3 antagonist.

The recommended dose of Aprepitant is 125 mg taken orally one hour before chemotherapy on day 1 and 80 mg once daily in the morning on days 2 and 3.

【Adverse reactions】

The most common drug-related adverse reactions of Aprepitant include: hiccups, weakness/tiredness, increased liver index ALT, constipation, headache, anorexia, etc.

Other adverse reactions of Aprepitant include: redness, upper respiratory tract infection, tachycardia, weakness, pelvic pain, bone pain, pelvic pain, rash, hypokalemia, anxiety, etc. Bradycardia, disorientation, perforated duodenal ulcer, and Stevens-Johnson syndrome have also been reported.

【Notes】

Corrections must be made when treating patients with Aprepitant and drugs that are primarily metabolized by the CYP3A4 enzyme; some chemotherapy drugs are metabolized by the CYP3A4 enzyme. The inhibitory effect of Aprepitant on CYP3A4 will lead to increased blood concentrations of these concomitant drugs.

Aprepitant (Aprepitant) used together with warfarin can lead to shortening of the prothrombin time (prothrombin time), expressed as the International Normalized Ratio (INR). For patients receiving long-term warfarin therapy, the prothrombin tim INR should be strictly monitored after each three-day course of Aprepitant treatment to maintain and maintain the required warfarin dose.

Long-term use of Aprepitant may reduce the effectiveness of oral contraceptives. Although the effects of a three-day regimen of Aprepitant on oral contraceptives have not been studied, an alternative or complementary method of contraception should be used during use of Aprepitant.

Note: The above information comes from the Internet and is compiled and edited by Medical Companion Travel (please correct me if there are any errors or omissions). It is only to provide information on the latest drugs on the market in the world and help Chinese patients understand the latest international new drug trends. It is only for internal discussion among medical staff and does not serve as any basis for medication. For specific medication guidelines, please consult the attending physician.

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