止吐药阿瑞匹坦是在化疗前还是化疗后服用？

Many patients take medications that can cause vomiting during chemotherapy. They are used to prevent postoperative nausea and vomiting, or are used in combination with other antiemetics to prevent nausea and vomiting caused by chemotherapy drugs. However, many patients do not understand when to take aprepitant. Today we will take a detailed look at whether the antiemetic drug aprepitant should be taken before or after chemotherapy?

Aprepitant can be taken with or without food. Aprepitant capsules need to be swallowed whole and it is not recommended to chew or open the capsules; they must not be used in combination with terfenadine, pimozide, cisapride, and astemizole. It is recommended to take 125 mg of aprepitant orally one hour before chemotherapy and 80 mg in the morning of the second and third days. Aprepitant 40m should be taken 3 hours before anesthesia surgery to prevent vomiting. When taking the medicine, patients should not only follow the doctor's instructions, but also read the instructions carefully. Do not change the dosage and usage at will, so as not to affect the effect of the medicine and aggravate the original condition.

Aprepitant is a new type of antiemetic drug that was launched in the United States in 2003. It is a neurokinin-1 (neuronkinin-1, NK-1) receptor antagonist. Aprepitant has the advantages of strong affinity, high selectivity, long half-life, etc., and has potential therapeutic effects on pain, migraine, anxiety, depression, etc., and has broad clinical application prospects. Aprepitant is a gray-white to yellowish crystal-like solid chemical. The most common adverse reactions include: increased liver index ALT, hiccups, weakness/tiredness, constipation, headache and anorexia.

Taking aprepitant before chemotherapy can delay the symptoms of nausea and vomiting caused by chemotherapy. Taking aprepitant during chemotherapy can very well delay these symptoms and can also well reduce the patient's pain. The effective time of aprepitant is related to specific diseases and drugs. The test showed that 94 patients with lung cancer were treated with aprepitant on the basis of the same cisplatin-containing regimen as the control group. The results proved that the aprepitant group was 83.3% effective in treating acute vomiting and 92.6% in delayed vomiting. The effect was significant and could improve the patients' quality of life.

Note: The above information comes from the Internet and is compiled and edited by Medical Companion Travel (please correct me if there are any errors or omissions). It is only to provide information on the latest drugs on the market in the world and help Chinese patients understand the latest international new drug trends. It is only for internal discussion among medical staff and does not serve as any basis for medication. For specific medication guidelines, please consult the attending physician.

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