阿瑞匹坦Aprepitant副作用有哪些？治疗时要注意什么

Aprepitant is a beta/neurokinin-1 (NK1) receptor antagonist indicated for use in combination with other antiemetics for the prevention of acute and delayed nausea and vomiting associated with initial and repeated courses of highly emetogenic cancer chemotherapy (HEC), including high-dose cisplatin, and for the prevention of nausea and vomiting associated with initial and repeated courses of moderately emetogenic cancer chemotherapy (MEC). As with most medicines, there are some side effects associated with treatment with this medicine. What are the side effects? What should I pay attention to during treatment?

Aprepitant includes: redness, upper respiratory tract infection, tachycardia, elevated liver index ALT, constipation, pelvic pain, bone pain, rash, hypokalemia, anxiety, hiccups, weakness/tiredness, headache, anorexia, perforated duodenal ulcer, Stevens-Johnson syndrome, etc. The number, time and severity of Aprepitant side effects are all determined by the patient's tolerance to the drug, physical condition, and disease progression. Therefore, each patient's side effects are different. Patients should strictly follow the correct method of medication to avoid further adverse reactions.

Aprepitant Precautions

Pay attention to drug interactions when using Aprepitant, and avoid using this drug in combination with pimozide, terfenadine, astemizole, cisapride and other drugs. Aprepitant produces a dose-dependent inhibition of cytochrome P450 isoenzyme 3A4 (CYP3A4), thereby increasing the plasma concentrations of these drugs, which may cause serious or life-threatening adverse reactions. If patients are taking other medications, they should inform their doctor before receiving aprepitant, and the doctor will diagnose whether they can be taken at the same time.

Long-term treatment with Aprepitant may reduce the efficacy of oral contraceptives, so patients should use an alternative or complementary method of contraception while receiving this drug.

Note: The above information comes from the Internet and is compiled and edited by Medical Companion Travel (please correct me if there are any errors or omissions). It is only to provide information on the latest drugs on the market in the world and help Chinese patients understand the latest international new drug trends. It is only for internal discussion among medical staff and does not serve as any basis for medication. For specific medication guidelines, please consult the attending physician.

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