埃索美拉唑治疗胃食管反流性疾病效果如何？

How effective is esomeprazole in treating gastroesophageal reflux disease? Clinical observation of the clinical efficacy of esomeprazole (Nexium) in the treatment of refractory gastroesophageal reflux disease (rGERD). Methods: 64 patients with GERD who were ineffective after 4 weeks of first-generation proton pump inhibitor (PPI) treatment were randomly divided into 2 groups. 32 patients in the observation group were given esomeprazole 20 mg, bid, and mosapride 5 mg, tid; 32 patients in the control group were given esomeprazole 20 mg, bid. mg, bid, repeat endoscopy after 4 weeks and 8 weeks of treatment, and evaluate clinical symptoms.

Results: After 4 weeks of treatment, the symptom scores of both groups were significantly lower than before treatment (P<0.05). After 8 weeks of treatment, the symptom scores and endoscopic grading of both groups were significantly improved compared with those before treatment (P<0.05). Conclusion: Conventional doses of esomeprazole are fast and effective in the treatment of refractory GERD, and its long-term efficacy does not depend on mosapride. Combining mosapride with mosapride is beneficial to improving the early efficacy of esomeprazole.

Esomeprazole is a proton pump inhibitor. The chemical name of esomeprazole is S-5-methoxy-2-{[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]sulfinyl}-1H-benzimidazole. It can reduce gastric acid secretion by inhibiting specific proton pumps, and has a good inhibitory effect on both basic gastric acid secretion and stimulated gastric acid secretion. Clinically, it is mainly suitable for patients with gastroesophageal reflux disease who cannot take oral medication and gastroduodenal ulcer bleeding. Since esomeprazole sodium for injection has a strong inhibitory effect on gastric acid secretion, it cannot be used for a long time, and the general course of treatment does not exceed 7 days. For patients who cannot take oral medication, it is recommended to inject 20-40 mg of this product intravenously or intravenously once a day. Patients with reflux esophagitis should use 40 mg once daily; for symptomatic treatment of reflux disease, 20 mg should be used once daily.