埃索美拉唑治疗胃食管反流性疾病疗效怎么样？

Esomeprazole is an original drug produced by AstraZeneca, with the trade name Nexium and the generic name esomeprazole magnesium enteric-coated tablets (former name: esomeprazole magnesium enteric-coated tablets). Esomeprazole capsules have been approved and sold in more than 120 countries around the world. A Phase III clinical study of esomeprazole capsules in the treatment of reflux esophagitis conducted in Japan showed rapid symptom relief, endoscopic healing and good tolerability and safety.

Esomeprazole (Nexium) is the S-optical isomer of omeprazole and the world's first isomer proton pump inhibitor (PPI). It reduces gastric acid secretion by specifically inhibiting the proton pump of gastric parietal cells. It has been confirmed by a large number of clinical experiments and drug research: it can maintain gastric pH>4 for a longer time, has higher acid suppression efficiency, and is more effective than the previous two generations of PPI, with small individual differences. As a new generation of PPI, it has been widely used in clinical treatment of many acid-related diseases. How effective is esomeprazole in the treatment of gastroesophageal reflux disease?

The U.S. Food and Drug Administration (FDA) has approved Nexium (esomeprazole magnesium extended-release capsules), the first generic version of AstraZeneca’s proton pump inhibitor, for the treatment of gastroesophageal reflux disease (GERD) in adults and children ≥1 year of age. Clinical trials have shown that esomeprazole (Nexium) can inhibit gastric acid secretion in children with gastroesophageal reflux disease (GERD) and has a significant therapeutic effect.

On July 30, 2020, AstraZeneca announced that China’s National Medical Products Administration (NMPA) officially approved Nexium (esomeprazole sodium) injection for the prevention of stress ulcer bleeding in severe patients. According to Medical Travel, the price of the Japanese version of esomeprazole (Nexium) is about 1,900, and the Indian version is about 500.