服用耐信的注意事项

(Esomeprazole) is a new generation of proton pump inhibitor (PPI), mainly suitable for the treatment of peptic ulcers. Compared with other proton pump inhibitors, Nexium has the advantages of shorter treatment course, more stable efficacy, faster and longer onset of action, and higher HP ulcer eradication rate. It is the latest generation of drugs currently used to treat peptic ulcers. Today we will learn more about the precautions for taking Nexium.

Fractures: Treatment with proton pump inhibitors (PPIs) can increase the incidence of osteoporosis-related fractures of the hip, spine, or wrist. Patients receiving high-dose or long-term treatment (≥1 year) with Nexium should be monitored. Use the lowest effective dose of Nexium for the shortest possible time, supplement with vitamin D and calcium, and follow appropriate guidelines to reduce the risk of fractures in high-risk patients.

Fundic gland polyps: Use of proton pump inhibitors (PPIs) increases the risk of fundic gland polyps, especially in patients with long-term use for more than 1 year. It may be asymptomatic, but nausea, vomiting, or abdominal pain may occur; gastrointestinal bleeding or anemia may occur with ulcerative polyps. A diagnosis of polyps may also increase the risk of small bowel obstruction. Nexium (esomeprazole) uses the lowest dose and shortest duration of PPI (proton pump inhibitor) treatment appropriate to treat the disease.

Hypomagnesemia: Rarely reported, usually with long-term PPI (proton pump inhibitor) use for ≥3 months (most cases >1 year of treatment). Nexium may be symptomatic or asymptomatic; severe cases may cause tetany, seizures, and irregular heartbeats. Consider obtaining serum magnesium concentrations before initiating long-term therapy, especially if digoxin, diuretics, or other drugs known to cause hypomagnesemia are concurrently administered and regularly thereafter. Hypomagnesemia can be corrected with magnesium supplementation and may require discontinuation of Nexium. Magnesium levels usually return to normal within 1 week after stopping the medication. 

Vitamin B12 Deficiency: Long-term treatment (≥2 years) with Nexium (esomeprazole) may result in vitamin B12 malabsorption and subsequent vitamin B12 deficiency. The degree of deficiency is dose-related, with a stronger association in women and younger individuals (under 30 years of age); the prevalence decreases after discontinuation of treatment.

The above is the content of the precautions for (esomeprazole), I hope it can help you!

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