罗氟司特乳膏(roflumilast)2024年的价格是多少钱一支?

The price of roflumilast cream in 2024

Roflumilast cream has not been launched in China as of January 5, 2024. The price currently known is about 12,420$ per box, but it is not fixed due to various factors.

The role and dosage of roflumilast cream (roflumilast)

Roflumilast cream (roflumilast) is a selective phosphodiesterase-4 (PDE4) inhibitor. By inhibiting this enzyme, roflumilast can reduce the inflammatory response, thereby helping to relieve the symptoms of skin diseases. Roflumilast cream is a nonsteroidal anti-inflammatory drug that inhibits cyclooxygenase and prostaglandin E2 synthesis. It can be used to treat plaque psoriasis in patients 12 years of age and older, including intertrigo areas.

Apply roflumilast cream to the affected area once daily and rub in thoroughly. Wash hands after application unless roflumilast cream is used to treat hands. Roflumilast cream is for topical use only and is not for eye, oral, or vaginal use.

The effect of roflumilast cream (roflumilast) in the treatment of psoriasis

Roflumilast cream (roflumilast) can inhibit the phosphodiesterase 4 inhibitor enzyme, leading to the accumulation of cyclic adenosine monophosphate, thereby inhibiting the inflammatory mediators interferon-γ and tumor necrosis factor-α. Roflumilast cream (roflumilast) is administered once daily, reaches steady state on day 15, and has a half-life of approximately 4 days in adults. The efficacy of roflumilast was evaluated in the DERMIS-1 and DERMIS-2 clinical trials.

In DERMIS-1, the overall investigator-assessed success rate was 42.4% for roflumilast cream and 6.1% for the drug (32.3%-46.9%; P <0.001). Similarly, in DERMIS-2, the overall investigator-assessed success rate for roflumilast cream was 37.5%, compared with 6.9% for the therapeutic agents.

Test conclusion

Topical application has certain efficacy in treating sensitive areas such as skin folds, and can replace systemic treatment for some patients. The U.S. Food and Drug Administration has approved topical roflumilast cream (roflumilast) for the treatment of plaque psoriasis, including in the intertrigeminal area, in patients 12 years of age or older.

Roflumilast Cream (roflumilast) Use in Specific Populations

1. Roflumilast Cream (roflumilast) is contraindicated in patients with moderate to severe liver impairment (Child-Pugh Class B or C);

2. There are insufficient data available on the use of roflumilast Cream (roflumilast) in pregnant women to inform drug-related risks of major birth defects, miscarriage, or other adverse maternal or fetal outcomes.

3. There is no data on the presence of roflumilast or its metabolites in breast milk, its impact on breastfed infants, or its impact on milk production.

4. The safety and effectiveness of roflumilast cream (roflumilast) in children under 6 years old has not been determined.

5. According to the existing data of roflumilast cream (roflumilast), there is no need to adjust the dosage of elderly patients

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References

Nicolas SE, Bear MD, Kanaan AO, Coman OA, Dima L. Roflumilast 0.3% Cream: a Phosphodiesterase 4 Inhibitor for the Treatment of Chronic Plaque Psoriasis. Am J Ther. 2023 Nov-Dec 01;30(6):e535-e542. doi: 10.1097/MJT.0000000000001678.PMID: 37921681.