贝罗司他胶囊作用功效是什么？贝罗司他胶囊应该如何使用

Hereditary angioedema (HAE) is a primary complement deficiency disease characterized by episodic, self-limiting, localized systemic cutaneous submucosal non-pitting edema. It is often accompanied by abdominal pain, nausea and vomiting, and a decrease in serum C1 esterase inhibitor (C1INH). Berotralstat is an oral capsule approved for the prevention of hereditary angioedema (HAE) attacks in patients 12 years of age and older. What's the effect? How should berostat capsules be used?

Berostat capsules functions and effects

Most HAEs are caused by a deficiency (type 1 HAE) or dysfunction (type 2 HAE) of a protein called C1 esterase inhibitor. Berotralstat is a plasma kallikrein inhibitor that binds to plasma kallikrein and inhibits its proteolytic activity.

It is the first and only preventive HAE drug approved in Japan. One daily capsule of berotralstat can prevent the onset of HAE by reducing plasma kallikrein activity.

Japan's APeX-J trial met its primary endpoint, with patients in the berotralstat group experiencing a significant reduction in the frequency of HAE attacks compared with placebo. Moreover, berosostat capsules are safe and generally tolerated in trials.

How to use berosostat capsules

Instructions for use of berosostat capsules: Take one capsule (150 mg) orally once a day with food. Taking more than one berotralstat capsule a day may cause QT prolongation, a condition that causes an abnormal heartbeat. Therefore, patients should not increase the dosage of medication without authorization during treatment, as this will produce other adverse reactions and affect the progression of the disease. Patients should strictly follow the doctor's diagnosis and treatment recommendations.

The above is an introduction to the functions and usage of berotralstat capsules. If patients want to know more about the latest drug information about this drug (such as the price of berotralstat capsules, purchase methods, etc.), they can contact the medical companion service at any time.

Note: The above information comes from the Internet and is compiled and edited by Medical Companion Travel (please correct me if there are any errors or omissions). It is only to provide information on the latest drugs on the market in the world and help Chinese patients understand the latest international new drug trends. It is only for internal discussion among medical staff and does not serve as any basis for medication. For specific medication guidelines, please consult the attending physician.

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