他克莫司软膏真的这么神奇吗？

Atopic dermatitis (AD) is a chronic, relapsing, inflammatory skin disease in which patients often experience severe itching, seriously affecting their quality of life. In recent years, in-depth research on the immune mechanism of AD has revealed that AD is the result of a vicious cycle of inflammatory response. Tacrolimus ointment is a new type of topical macrolide immunomodulator and a non-corticosteroid topical preparation for the treatment of AD. It has definite efficacy and few adverse reactions.

So, is tacrolimus ointment really so miraculous?

Studies have shown that the mechanism of action of tacrolimus ointment is mainly to inhibit the transcription of nuclear factor of activated T lymphocytes (NF-AT) by inhibiting calcineurin, thereby inhibiting the activation of T lymphocytes and the immune and inflammatory responses mediated by them. It can effectively bind to FK506-binding protein-12 in the cell cytoplasm and form a complex, competitively binding to calcineurin of calmodulin, inhibiting enzyme activity, and ultimately inhibiting the production of cytokines related to the pathogenesis of atopic dermatitis. This effect is to selectively target the core of the pathogenesis of AD.

Tacrolimus does not inhibit collagen synthesis, so long-term use will not cause skin atrophy at the treatment site and increase the probability of infection. It is highly safe and has significant advantages in the maintenance treatment of AD. In addition to inhibiting the expression of a large number of cytokines related to Th2 and Th1 cells by classically inhibiting the activity of calcineurin in T lymphocytes, tacrolimus can also directly or indirectly inhibit the activation of KC transcription factors NF-κBp50 and NF-κBp65, which are related to the initiation of inflammatory responses, thereby inhibiting the expression of pro-inflammatory cytokines, chemokines and costimulatory molecules regulated by NF-κB, resulting in an anti-innate immune inflammatory response.

Note: The above information comes from the Internet and is compiled and edited by Medical Companion Travel (please correct me if there are any errors or omissions). It is only to provide information on the latest drugs on the market in the world and help Chinese patients understand the latest international new drug trends. It is only for internal discussion among medical staff and does not serve as any basis for medication. For specific medication guidelines, please consult the attending physician.