特应性皮炎药物舒坦明的特殊人群用药和禁忌一文详解

Introduction: Sutamine (criboror ointment) is a topical drug used to treat atopic dermatitis and is a non-hormonal topical PDE-4 inhibitor. This article mainly talks about the medication of Sutami for special groups, medication contraindications, mechanism of action, usage and dosage, adverse reactions and treatment, dietary requirements, etc.

Usage in Special Populations

There are currently no relevant data on the use of Sutamine in pregnant women, and information on major birth defects and miscarriage risks associated with the drug cannot be provided. There is no data available on the presence of sutamine in human milk and the effects of this drug on the breastfed infant or on the effects of topical application of this drug on milk production in lactating women. Clinical studies of Sutatin did not include a sufficient number of elderly patients (over 65 years old) to determine whether they respond differently to this product than younger patients.

Contraindications

Sutamine is contraindicated in patients with known hypersensitivity to crisaborole or any component of this preparation. Patients should inform their doctor if they have a history of allergies before taking the medication.

Mechanism of action

The mechanism of action of Sutamine involves the inhibition of phosphodiesterase-4 (PDE-4). PDE-4 is responsible for reducing cyclic adenosine monophosphate (cAMP) levels within cells. When PDE-4 is inhibited, intracellular cAMP levels increase, which leads to the activation of protein kinase A (PKA), thereby inhibiting the production of a variety of inflammatory factors, including NFAT, NF-κB, CREB, Rap1 and Csk, etc., thus reducing the synthesis of inflammatory cytokines and playing a therapeutic role in inflammatory skin diseases.

Usage and Dosage

After cleaning the affected area (i.e. the affected area), take an appropriate amount of ointment (a thin layer) and gently apply it to the affected area. Sertamin is for external use only and is not suitable for oral, intraocular or vaginal administration. Apply twice daily, once in the morning and evening. Continue to use until symptoms subside.

Adverse reactions and treatment

Skin burning, stinging, swelling or inflammation, as well as skin redness, itching, hives, herpes or rash may occur during use. Severe itching, swelling, and erythema at or distant from the administration site may be signs of an allergic reaction. Some patients may also experience difficulty breathing or swallowing, as well as a rapid heartbeat. If the above adverse reactions occur when using the cream, you should stop using it immediately and seek medical treatment in time.

Dietary Requirements

If the patient is known to be allergic to certain foods or substances, they should be avoided as much as possible to reduce the risk of eczema or other allergic reactions. Avoid spicy and irritating foods: Spicy and irritating foods may irritate the skin and aggravate the symptoms of eczema. Avoid hair-raising foods: Hair-raising foods such as seafood, beef and mutton may cause allergic reactions and aggravate the symptoms of eczema. It is recommended that patients choose light and easy-to-digest foods during treatment, such as vegetables, fruits, porridge, etc., to maintain intestinal health and promote body metabolism.

Sutamine, as a non-hormonal, non-steroidal anti-inflammatory drug, provides a treatment option different from traditional glucocorticoids, and is especially suitable for topical treatment of patients with mild to moderate atopic dermatitis. It is recommended that patients take medication under the guidance of a doctor and receive symptomatic treatment.