特应性皮炎用药乌帕替尼的作用效果和副作用管理

Introduction: Upatinib is mainly used to treat a variety of immune-mediated inflammatory diseases. It can inhibit the activity of JAK1 kinase and interfere with intracellular signaling pathways, thereby inhibiting inflammatory responses. This article mainly talks about the indications, effects, side effects management, dietary attention, etc. of Upatinib.

Indications

1. Treatment of axial spondyloarthritis: Upadatinib extended-release tablets are approved for the treatment of active radiologically negative axial spondyloarthritis with poor response to NSAIDs and objective signs of inflammation.

2. Improvement of atopic dermatitis: In clinical studies, upadatinib has shown efficacy in patients with moderate to severe atopic dermatitis, including reduction of itching and improvement of clearance of skin lesions.

3. Treatment of rheumatoid arthritis and psoriatic arthritis: Upadatinib extended-release tablets are also included in the "National Basic Medical Insurance, Work Injury Insurance and Maternity Insurance Drug Catalog (2022)", covering these indications.

Effects

1. Anti-inflammatory effect: As a JAK inhibitor, upadatinib can block the phosphorylation and activation of STAT by regulating signaling pathways, thereby exerting anti-inflammatory effects.

2. Oral convenience: Upadatinib is taken orally, making it easier for patients to adhere to it, which is also very important to ensure the therapeutic effect.

3. Rapid onset of effect: Upadatinib has a rapid effect in treating atopic dermatitis. Patients can observe a rapid improvement in itching in the early stages of treatment, and the skin lesions show significant improvement in the 2nd week after treatment.

4. High selectivity: Upadatinib shows greater inhibitory potency against JAK1 than against JAK2, JAK3 and TYK2, indicating that it has high selectivity.

5. Potential for treating other indications: Researchers are studying upadatinib in several immune-mediated diseases, showing that it may have the potential to treat a variety of diseases.

Side Effects and Management

The side effects of Upatinib include upper respiratory tract infection, acne, viral infection, headache, elevated blood creatine phosphokinase level, cough, allergic reaction, hair follicle inflammation, stomach (abdominal) pain, fever, weight gain, flu-like symptoms, fatigue, low white blood cell count (neutropenia), muscle pain, etc. It is recommended that patients use Upatinib under the guidance of a doctor and undergo necessary examinations and evaluations regularly.

Because upadatinib may increase the risk of infection, patients should pay attention to any signs of infection, such as fever, cough, or unusual tiredness, and seek medical attention promptly. For skin side effects like acne, keeping your skin clean and using skin care products appropriately may help. Maintaining a healthy lifestyle, such as moderate exercise, a balanced diet, and getting enough sleep, can increase the body's resistance to side effects. While you are using upadacitinib, your doctor may recommend avoiding other medications that may increase your risk of side effects. If side effects are severe or persist, contact your doctor immediately.

Diet Notes

Maintain a balanced diet and eat more nutrient-rich foods, such as fresh fruits and vegetables, whole grains, and protein-rich foods. Avoid excessive intake of foods high in fat, salt and sugar. Avoid alcohol, which may increase the side effects of the medication, such as liver damage. Moderate physical activity can improve overall health and help reduce fatigue that may be caused by medications. Get enough sleep to help your body recover and reduce fatigue. Have regular physical exams, including blood tests and liver and kidney function tests, as recommended by your doctor to monitor the possible effects of the medication on these organs.

As a JAK inhibitor, it has shown positive effects in the treatment of immune-mediated inflammatory diseases, and has oral convenience and rapid onset of action. Patients should follow their doctor's instructions when using upadacitinib to ensure the safety and effectiveness of the treatment.