纳呋拉啡的不良反应有哪些？

1. Serious adverse reactions: liver dysfunction, jaundice (frequency unknown) Liver dysfunction, accompanied by significant increases in AST, ALT, Al-P, γ-GTP, etc., and sometimes jaundice.

2. Mental system: Patients may experience hallucinations, restlessness, severe drowsiness, insomnia, headache, floating dizziness, tremor, speech impairment, etc.

3. Digestive system: During treatment, patients may experience nausea, vomiting, abdominal pain, constipation, thirst, loss of appetite, gastritis, etc.

4. Skin reactions: Patients may develop rashes, urticaria, erythema, papules, pigmentation, eczema, etc.

5. Renal system: The use of nalfurapine can cause patients to experience symptoms such as polyuria, frequent urination, and frequent urination at night.

6. Circulatory system: such as heart palpitations, increased blood pressure, etc.

7. Urine: It may cause patients to have symptoms such as positive blood in urine and positive protein in urine.

8. Other symptoms: symptoms such as fatigue, chest discomfort, debility, elevated thyroid stimulating hormone, elevated prolactin, etc.

When used in hemodialysis patients, adverse reactions usually occur within 2 weeks of starting the injection. When used in patients with chronic liver disease, adverse reactions often appear within 4 weeks after taking the drug.

If patients experience serious adverse reactions during medication, they should go to the hospital in time and complete examinations under the guidance of a doctor to clarify the condition and evaluate whether it is necessary to stop the medication, switch to other medications, or adjust the dose of the medication to continue treatment to prevent adverse reactions from affecting health.

This preparation collapses in the mouth, but its effect is not achieved through absorption through the oral mucosa, so it should be swallowed with saliva or water. The patient can put it on the tongue, soak it with saliva, mash it gently with the tongue, and take it with saliva alone after collapse. In addition, it can also be taken with water.

Generally, adults take 2.5 μg (calculated as nalfurafine hydrochloride) once a day, orally after dinner or before going to bed. In addition, the dose can be increased according to symptoms, but it is limited to 5 μg once a day.

It should be noted that the medicine packaged in PTP should be taken out of the PTP sheet and instructed to take it. Due to accidental ingestion of PTP tablets, the hard sharp corners penetrate into the esophageal mucosa, even causing perforation and serious complications such as mediastinal sinusitis. When not in use, it should be stored directly in aluminum foil packaging (containing deoxidizer).

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