盐酸纳呋拉啡的用法用量,注意事项及药物相互作用

Author: Medicalhalo

Release time: 2025-10-19 11:44:20

It is a selective opioid kappa receptor agonist. It exerts an anti-itching effect through a new mechanism of action that is completely different from existing antihistamines or anti-allergic drugs. Clinical applications abroad have found that the drug still has a significant effect on hemodialysis pruritus that is resistant to existing treatments, and can significantly improve patients' refractory skin itching and sleep quality problems. The following introduces the usage, dosage, precautions and drug interactions of nalfuraphine hydrochloride.

Dosage and dosage of nalfuraphine hydrochloride

The usual oral dosage of nalfurapine hydrochloride for adults is 2.5 ug, once a day, after meals or before going to bed. The dose may be increased based on symptoms but should be limited to 5 mcg once daily.

Nafurafine Hydrochloride Usage and Dosage for Special Populations

1. Patients with renal dysfunction: blood drug concentration may increase.

2. Patients with liver dysfunction.

(1) Patients with severe (Child-Pugh Class C) liver disease: No clinical studies have been conducted on patients with severe (Child-Pugh Class C) liver damage.

(2) Patients with moderate (Child-Pugh classification B) liver function impairment. Plasma concentrations may increase.

3. Pregnant women: Pregnant women or women who may become pregnant should not take this product. Placental passage, reduced number of viable fetuses, reduced birth rate, and reduced birth weight have been reported in animal studies (rats).

4. Breastfeeding mothers: When considering the treatment effect and the benefits of breastfeeding, you should consider continuing or stopping breastfeeding. In animal studies (rats), the drug has been reported to be transferred into breast milk.

5. Children: No clinical trials have been conducted on children or other subjects.

6. Elderly people: Medication should be used with caution while monitoring the patient's condition. In general, physiological functions are usually impaired.

Nafurafine Hydrochloride Medication

1. Sufficient time should be left between taking clozapine and starting hemodialysis. Because hemodialysis removes the drug, clozapine blood concentrations may decrease if the time between taking clozapine and hemodialysis is short.

2. There should be sufficient interval between administration of clozapine and replacement of dialysate. If the interval between clozapine administration and dialysate exchange is short, clozapine plasma concentrations may be reduced.

3. The dosage of this drug should start from 2.5 micrograms once a day. If the effect is not enough, an increase to 5 micrograms once a day should be considered.

4. When taking this product to patients with severe (Child-Pugh Class C) liver function impairment, the patient's condition should be carefully monitored during the medication period and the risk-benefit ratio should be considered.

5. Drowsiness and dizziness may occur, so patients receiving this drug should be careful not to engage in the operation of dangerous machinery, such as driving a car.

6. If no effect is observed after using this medicine, be careful not to use it carelessly for a long time.

7. Endocrine abnormalities such as increased prolactin levels may occur after taking this product, and testing should be conducted as appropriate.

Drug interactions with nalfuraphine hydrochloride

1. Drugs that inhibit CYP3A4

Azole antifungals (itraconazole), midromycin, ritonavir, cyclosporine, nifedipine, cimetidine, grapefruit juice, etc. Because plasma concentrations of the drug may be increased, patients should be carefully observed when initiating use, changing dosage, or discontinuing concurrent use.

Concomitant use of CYP3A4 inhibitors with other drugs may inhibit the metabolism of the drug and increase its plasma concentrations.

2. Sleeping pills, anti-anxiety drugs, antidepressants, antipsychotics, and antiepileptic drugs

Insomnia, hallucinations, drowsiness, dizziness, tremors and delirium may occur when using this product at the same time. Therefore, care should be taken to avoid adverse reactions when starting, changing the dose, or discontinuing this product. The central adverse effects of the drug may be enhanced.