阿托伐他汀与瑞舒伐他汀有什么区别？

Coronary heart disease (CHD) is caused by coronary atherosclerosis (AS) lesions that lead to vascular stenosis or even obstruction, which blocks the blood circulation of the heart and causes myocardial necrosis due to lack of blood/oxygen supply. Heart failure is often the final stage. Because AS lesions are irreversible, there is currently no cure, but effective intervention such as diet, drugs, and surgery can delay or prevent the progression of the disease. Hyperlipidemia is an independent risk factor for cardiovascular disease, and lipid-lowering drugs are often used clinically to prevent and treat CHD. Studies have confirmed that statins have positive significance in improving the prognosis of patients with CHD. Among them, rosuvastatin and rosuvastatin are both 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) selective inhibitors. The former is rapidly absorbed orally and has a long half-life. It can effectively reduce blood total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) levels. The adverse reactions are mild and can be well tolerated. It is effective in preventing and treating AS and CHD; the latter has more powerful lipid-regulating and anti-inflammatory effects. So, what is the difference between atorvastatin and rosuvastatin?

Atorvastatin and rosuvastatin are commonly used clinical blood lipid regulating drugs. The main differences are:

1. Cholesterol-lowering effect: Rosuvastatin is stronger than atorvastatin.

2. The reversal effect on plaques: Rosuvastatin is higher than atorvastatin.

3. Anti-inflammatory effect: Atorvastatin is better than rosuvastatin.

4. Hepatotoxicity: The hepatotoxicity of atorvastatin is greater than that of rosuvastatin.

5. Myalgia: The myotoxicity of rosuvastatin is stronger than that of atorvastatin.

6. Nephrotoxicity: Atorvastatin is safer to the kidneys.

7. Drug interactions: Atorvastatin has more drug interactions than rosuvastatin.

The above is the difference between atorvastatin and rosuvastatin. Which one to use clinically must be determined by the relevant doctor. Do not use it yourself to avoid delaying your own treatment.

Note: The above information comes from the Internet and is compiled and edited by Medical Companion Travel (please correct me if there are any errors or omissions). It is only to provide information on the latest drugs on the market in the world and help Chinese patients understand the latest international new drug trends. It is only for internal discussion among medical staff and does not serve as any basis for medication. For specific medication guidelines, please consult the attending physician.