依普利酮国内价格

(Provisional name, Eplerenone, Inspra) is a selective aldosterone inhibitor originally developed by Pharmacia (Pfizer) and approved in the United States in October 2002 for the treatment of hypertension and congestive heart failure.

Eplerenone binds to mineralocorticoid receptors, thereby blocking the binding of aldosterone, a component of the renin-angiotensin-aldosterone system (RAAS). Aldosterone synthesis occurs primarily in the adrenal gland and is regulated by multiple factors, including angiotensin II and non-RAAS mediators such as adrenocorticotropic hormone (ACTH) and potassium. Aldosterone binds to mineralocorticoid receptors in epithelial tissues (such as the kidneys) and non-epithelial tissues (such as the heart, blood vessels, and brain) and increases blood pressure by inducing sodium reabsorption and possibly other mechanisms.

Eplerenone can be used for congestive heart failure after acute myocardial infarction. Eplerenone can improve the quality of life of patients with left ventricular dysfunction (ejection fraction ≤ 40%). Clinical trials have proven that this product can also be used for congestive heart failure after acute myocardial infarction.

The commonly used domestic aldosterone receptor antagonist spironolactone has a significant protective effect on the cardiovascular system, but its sex hormone-related side effects limit its application. Eplerenone, as a new generation of selective aldosterone receptor antagonist, provides a new method for the treatment of cardiovascular diseases.

Eplerenone is not officially on the market in China, but it was approved for clinical use by the State Food and Drug Administration in 2002. Now it is generally favored by domestic doctors. Its effect is stronger than spironolactone and has almost no side effects.

Since it has not yet been launched in China, domestic hospitals cannot buy this drug. However, Medical Travel has learned that eplerenone from India's Lupine Pharmaceuticals, 50mg*100 tablets, costs around RMB 500, which is a price that is easily accepted by the public.