依普利酮国内的价格

Binds to mineralocorticoid receptors, thereby blocking the binding of aldosterone, a component of the renin-angiotensin-aldosterone system (RAAS). Aldosterone synthesis occurs primarily in the adrenal gland and is regulated by multiple factors, including angiotensin II and non-RAAS mediators such as adrenocorticotropic hormone (ACTH) and potassium. Aldosterone binds to mineralocorticoid receptors in epithelial tissues (such as the kidneys) and non-epithelial tissues (such as the heart, blood vessels, and brain) and increases blood pressure by inducing sodium reabsorption and possibly other mechanisms.

Eplerenone selectively acts on aldosterone receptors and is highly selective for mineralocorticoid receptors, but has less effect on androgen and progesterone receptors. Its affinity for mineralocorticoids is 15 to 20 times that of spironolactone, while its affinity for androgen and progesterone receptors is 500 times smaller than that of spironolactone, so sex hormone-related adverse reactions are less likely to occur.

The dosage for treating high blood pressure in adults is as follows: Eplerenone can be used alone or in combination with other antihypertensive drugs. Initial dose: 50 mg orally once daily, Maintenance dose: 50 mg orally once or twice daily, Maximum dose: 100 mg/day. Obvious antihypertensive effects appear within four weeks of taking the drug. Patients whose blood pressure responds inadequately to the initial dose may be increased to 50 mg twice daily.

Eplerenone (Inspra) is a selective aldosterone inhibitor originally developed by Pharmacia (Pfizer) and approved in the United States in October 2002 for the treatment of hypertension and congestive heart failure.

Since eplerenone is not currently on the market in my country, there is no domestic quotation for eplerenone, and patients cannot buy eplerenone in domestic pharmacies. In 2002, eplerenone was approved for clinical use by the State Food and Drug Administration, and is now generally favored by domestic doctors. Its effect is stronger than spironolactone and has almost no side effects.

Patients can choose to buy 50mg*100 tablets from Lupine Pharmaceuticals in India. The price is equivalent to about RMB 500, which is very cheap and the effect is basically the same as the original drug in the United States.