依普利酮的疗效如何呢？

It can be used alone or in combination with other antihypertensive drugs for the treatment of hypertension. How effective is eplerenone?

The clinical trial included 499 patients with grade 1 or 2 hypertension to analyze the effect of enalapril or eplerenone in treating hypertension. Patients were randomized to receive enalapril or eplerenone.

A comparative study on the efficacy and tolerability of 499 patients with grade 1 or 2 hypertension who were randomized to receive enalapril or eplerenone showed that at 6 months, enalapril was as effective as eplerenone in reducing systolic blood pressure (eplerenone reduced 14.5 mmHg; enalapril reduced 12.7 mmHg: P=0.199) and diastolic blood pressure (eplerenone reduced 11.2 mmHg; enalapril reduced 11.3 mm Hg; P=0.910). After 12 months, the two groups were also similar (eplerenone -16.5/-13.3mmHg; enalapril -14.8/-14.1mmHg, P values ​​0.251 and 0.331 respectively). Dropout due to adverse events (7.9% for eplerenone and 9.3% for enalapril at 6 months) and treatment failure rates were also equal (23.3% for eplerenone and 22.8% for enalapril at 6 months). About 2/3 of the patients in each group achieved normal blood pressure at 6 months with the above single treatment. In the eplerenone group, the reduction in blood pressure was independent of renin levels, unlike enalapril. Both groups could reduce proteinuria above normal levels, but the eplerenone group was more significant (-61.5% vs -25.7%; P=0.01).

Subgroup analysis of the study showed that the effect of eplerenone on reducing overall mortality was more pronounced in patients with hypertension. Not only that, it can improve the quality of life of patients with left ventricular dysfunction (ejection fraction ≤ 40%). Clinical trials have proven that eplerenone can also be used for congestive heart failure after acute myocardial infarction.