依普利酮治疗高血压疗效怎么样？

It is a new type of selective aldosterone receptor antagonist that was approved for clinical use by the US National Food and Drug Administration in 2002. Eplerenone is mainly used for the treatment of congestive heart failure and hypertension after acute myocardial infarction.

How effective is eplerenone in treating hypertension? 

Clinical trials evaluate the clinical efficacy and safety of eplerenone and losartan in the treatment of essential hypertension. Methods 80 patients were selected and randomly divided into eplerenone group and losartan group, 40 cases in each group. Eplerenone tablets 50 mg and Losartan potassium tablets 50 mg were administered orally once/d for 12 weeks. Before and after treatment, a number of biochemical indicators, 24-hour ambulatory blood pressure, and adverse reactions were mainly detected. Results Compared with before treatment, the blood pressure of the two groups dropped significantly, and the differences were statistically significant (P0.05); comparing the two groups, there was no statistically significant difference in the blood pressure reduction between eplerenone and losartan (P0.05). Comparing the biochemical indicators between the two groups, the difference was not statistically significant (P0.05).

The conclusion shows that eplerenone is a good medicine for the treatment of hypertension. It has a protective effect on the liver, heart, and kidneys without damaging the organs. This medicine can promote urination without losing potassium. Eplerenone and losartan. 1 time/d. Taking 50 mg can effectively control blood pressure in patients with mild and moderate hypertension. Good safety and compliance.

Usual dosage of eplerenone in adults with congestive heart failure

Initial dose: 25 mg orally, once a day; and within 4 weeks, gradually increase to the target dose as tolerated by the patient. The target dose is: 50 mg, orally, once a day.

Common doses of eplerenone for adults with hypertension

It can be used alone or in combination with other antihypertensive drugs. Initial dose: 50 mg, taken orally, once a day. Maintenance dose: 50 mg, taken orally, 1-2 times a day. Maximum dose: 100 mg/day. Obvious antihypertensive effects appear within four weeks of taking the drug. Patients whose blood pressure responds inadequately to the initial dose may be increased to 50 mg twice daily.