eplerenone效果好吗？

Binds to mineralocorticoid receptors, thereby blocking the binding of aldosterone, a component of the renin-angiotensin-aldosterone system (RAAS). Aldosterone synthesis occurs primarily in the adrenal gland and is regulated by multiple factors, including angiotensin II and non-RAAS mediators such as adrenocorticotropic hormone (ACTH) and potassium. Aldosterone binds to mineralocorticoid receptors in epithelial tissues (such as the kidneys) and non-epithelial tissues (such as the heart, blood vessels, and brain) and increases blood pressure by inducing sodium reabsorption and possibly other mechanisms.

How effective is eplerenone?

Clinical trials evaluate the clinical efficacy and safety of eplerenone and losartan in the treatment of essential hypertension. Methods: 80 patients were selected and randomly divided into eplerenone group and losartan group, 40 cases in each group. Eplerenone tablets 50 mg and losartan potassium tablets 50 mg were given orally once/d for 12 weeks. Before and after treatment, a number of biochemical indicators, 24-hour ambulatory blood pressure, and adverse reactions were mainly detected. Results Compared with before treatment, the blood pressure of the two groups dropped significantly, and the differences were statistically significant. Comparing the two groups, there was no statistically significant difference in the blood pressure reduction between eplerenone and losartan. Comparing the biochemical indicators between the two groups, the difference was not statistically significant. The conclusion shows that eplerenone is a good medicine for the treatment of hypertension. It has a protective effect on the liver, heart, and kidneys without damaging the organs. This medicine can promote urination without losing potassium. eplerenone versus losartan. 1 time/d. Taking 50mg can effectively control the blood pressure of patients with mild and moderate hypertension. Good safety and compliance.

The side effects of eplerenone include: cough, diarrhea, abdominal pain, angina, myocardial infarction, proteinuria, headache, dizziness, fatigue, flu-like symptoms, etc. Other adverse reactions include: gynecomastia, abnormal vaginal bleeding; increases (serum potassium, triglycerides, cholesterol, alanine aminotransferase, γ-glutamyl transferase, creatinine, uric acid levels), and decreases in serum sodium levels.