Planep说明书

Planep Instructions

[Drug name] Eplerenone, Planep, Inspra

[Planep indications]

1. Anti-hypertensive: Planep can be used alone or in combination with other anti-hypertensive drugs for the treatment of hypertension.

2. Congestive heart failure after acute myocardial infarction: Planep can improve the quality of life of patients with left ventricular dysfunction (ejection fraction ≤ 40%). Clinical trials have proven that Planep can also be used for congestive heart failure after acute myocardial infarction.

[Usage and dosage of Planep]

1. Congestive heart failure after acute myocardial infarction: The recommended dose is 50 mg/time, once a day. The initial dose should be 25 mg/time, once a day. Within 4 weeks, the dose should be gradually increased to 50 mg/time, once a day if the patient tolerates it.

2. Anti-hypertensive: Planep can be used alone or in combination with other anti-hypertensive drugs. The recommended initial dose for use alone is 50 mg once a day. Obvious pressure-reducing effect will appear within four weeks of taking the medicine. If the pressure effect is not obvious, it can be increased to 50mg/time, once a day. Higher dosages are not recommended, otherwise there is an increased risk of adverse reactions such as hyperkalemia.

[Adverse reactions to Planep]

The main adverse reactions include: cough, diarrhea, abdominal pain, angina, myocardial infarction, proteinuria, headache, dizziness, fatigue, flu-like symptoms, etc.

Other adverse reactions include: gynecomastia, abnormal vaginal bleeding; increased levels of serum potassium, triglycerides, cholesterol, alanine aminotransferase, γ-glutamyl transferase, creatinine, and uric acid, and decreased serum sodium levels.

【Notes on Planep】

Planep cannot be combined with potassium supplements, potassium-containing salts or contraindicated drugs (potassium-sparing diuretics, strong inhibitors of CYP450 liver enzymes).

Non-steroidal anti-inflammatory drugs and lithium can affect the plasma concentration of Planep and affect its efficacy.

People with high serum potassium, type 2 diabetes patients with microalbuminuria, high serum creatinine levels, and muscle clearance <50 mL/min should not take Planep.