服用依普利酮的注意事项

(Inspra) is used to treat hypertension and left ventricular dysfunction after acute myocardial infarction. It can effectively lower blood pressure, improve cardiac function, and reduce myocardial damage. In order to avoid harm to patients due to incorrect medication, patients also need to carefully understand the precautions for taking eplerenone.

1. The use of eplerenone may cause hyperkalemia, and the risk increases with proteinuria, diabetes, renal impairment, and patients taking angiotensin II inhibitors, angiotensin-converting enzyme (ACE) inhibitors, nonsteroidal anti-inflammatory drugs, or moderate CYP3A inhibitors at the same time. Close monitoring is required during treatment.

2. Use with caution in patients with diabetes and heart failure after myocardial infarction (especially those with proteinuria), as this may increase the risk of hyperkalemia.

3. Patients with mild renal impairment should use it with caution, because as renal function declines, the risk of hyperkalemia will increase. The drug may be discontinued according to the patient's degree of impairment. Use with caution in patients with moderate to severe liver damage.

4. The phenomenon of heart failure also occurs in the treatment of eplerenone (Inspra). When evaluating patients with heart failure to receive eplerenone treatment, the epidermal growth factor receptor (eGFR) should be greater than 30ml/min/1.73m2 or the creatinine should be less than or equal to 2.5mg/dL (men) or less than or equal to 2mg/dL (women) with no recent deterioration, potassium less than 5meq/L and no history of severe hyperkalemia. If blood potassium levels are elevated, close monitoring and management are required. If serum potassium is >6 meq/L, treatment should be discontinued.

5. Drug-drug interactions: (Inspra) may have significant interactions with a variety of drugs, which may require adjustment of drug dosage or selection of alternative therapies. Products containing potassium salt substitutes, potassium supplements, potassium-rich diets, or other drugs that may cause hyperkalemia (e.g., other potassium-sparing diuretics, nonsteroidal anti-inflammatory drugs) should be avoided. Concomitant use of potassium supplements or potassium-sparing diuretics is contraindicated in the treatment of hypertension.

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