依普利酮能长期服用吗

The new generation of selective aldosterone antagonist (eplerenone) was developed by Pfizer/Pharmacia under the trade name Inspra. It was first launched in the United States in 2002 and is used for the treatment of hypertension, heart failure and myocardial infarction. It has definite efficacy in treating hypertension, heart failure and myocardial infarction, has fewer adverse reactions and is well tolerated. Its outstanding advantage is that for severe hypertension that cannot be controlled by a combination of multiple antihypertensive drugs, the addition of this product can significantly reduce blood pressure, especially the systolic blood pressure. For patients with severe heart failure and myocardial infarction, the combination of this product with angiotensin-converting enzyme inhibitors (ACEI) and beta-blockers can improve the quality of life and reduce mortality.

Can eplerenone be taken long-term? Eplerenone can be used until drug resistance develops. Eplerenone requires a certain period of time to achieve the best effect of lowering blood pressure. It is also very safe when used in combination with other antihypertensive drugs. Therefore, it is recommended that when taking eplerenone early, it can be combined with other antihypertensive drugs to control blood pressure. After eplerenone reaches the peak effect, it can be used alone.

Common dosage for adults with congestive heart failure: initial dose, 25 mg orally, once daily; gradually increase to target dose within 4 weeks as tolerated by the patient. Target dose, 50 mg orally, once daily.

Common dosages for adults with hypertension: It can be used alone or in combination with other antihypertensive drugs. Initial dose: 50 mg orally, once daily; Maintenance dose: 50 mg, orally, once or twice daily; Maximum dose: 100 mg/day. Obvious antihypertensive effects appear within four weeks of taking the drug. Patients whose blood pressure responds inadequately to the initial dose may be increased to 50 mg twice daily.