降压药依普利酮的作用

(Eplerenone) is a new type of selective aldosterone receptor blocker that can effectively control hypertension, reduce damage to target organs such as the heart, brain and kidneys, and improve microalbuminuria in patients with type 2 diabetes. Eplerenone is a new type of selective aldosterone receptor antagonist that was approved for clinical use by the State Food and Drug Administration in 2002. It has stronger aldosterone antagonism than spironolactone and has extremely low affinity for androgen and progesterone receptors. It has few adverse reactions. It has definite efficacy in the treatment of hypertension, heart failure and myocardial infarction. It has fewer adverse reactions and good tolerance. It is a good alternative drug to spironolactone.

Eplerenone is a selective aldosterone receptor antagonist that only acts on mineralocorticoid receptors but not on androgen and progesterone receptors. Eplerenone treats patients with stage 1 and stage 2 hypertension with similar efficacy rates and reductions in systolic and diastolic blood pressure as enalapril. Eplerenone also has a good antihypertensive effect in patients with essential hypertension with low renin levels for whom angiotensin-converting enzyme inhibitors and angiotensin II receptor inhibitors are not effective. It also has a good antihypertensive effect on simple systolic hypertension, and has a good antihypertensive effect on diet-induced obesity-related hypertension.

Precautions for use: (1) This product cannot be used in combination with potassium supplements, potassium-containing salts or contraindicated drugs (potassium-sparing diuretics, strong inhibitors of CYP450 liver enzymes). (2) Non-steroidal anti-inflammatory drugs and lithium can affect the blood concentration of this product and affect its efficacy. (3) Patients with high serum potassium, type 2 diabetes patients with microalbuminuria, patients with high serum creatinine levels, and patients with muscle intoxication clearance <50 mL/min should not take this product. (4) Pregnant women, children, and those with hepatic insufficiency, chronic cardiac insufficiency, and renal insufficiency should use with caution.