依普利酮可以长期服用吗

(eplerenone) is a selective aldosterone receptor antagonist with a similar structure to aldosterone. It can block the sodium-preserving potassium excretion and water retention effects of aldosterone, thus acting as a potassium-preserving diuretic. Eplerenone is effective in reducing systolic blood pressure in patients with resistant hypertension. The European Hypertension Guidelines recommend aldosterone receptor antagonists as a treatment for resistant hypertension, and the Japanese Hypertension Guidelines also recommend them as the fourth drug in combination therapy.

Can eplerenone be taken long-term?

Eplerenone was first launched in the United States in 2002 for the treatment of hypertension, heart failure and myocardial infarction. It has definite efficacy in treating hypertension, heart failure and myocardial infarction, has fewer adverse reactions and is well tolerated. Eplerenone can be used until drug resistance develops. Eplerenone requires a certain period of time to achieve the best effect of lowering blood pressure. It is also very safe when combined with other antihypertensive drugs. Therefore, it is recommended that when taking eplerenone early, it can be combined with other antihypertensive drugs to control blood pressure. After eplerenone reaches the peak effect, it can be used alone.

The initial dose of eplerenone for the treatment of congestive heart failure is 25 mg orally once daily; increase to the target dose within four weeks as tolerated by the patient. The target dose is 50 mg orally once daily. 

When treating adult patients with hypertension, eplerenone can be used alone or in combination with other antihypertensive drugs. It is administered orally. The initial dose is 50 mg, once a day; the maintenance dose is 50 mg, 1-2 times a day. The maximum dose is 100 mg/day and patients should not overdose. Typically, significant blood pressure lowering effects occur within four weeks of taking eplerenone. Patients whose blood pressure responds inadequately to the initial dose may be increased to 50 mg twice daily.

  The above is the introduction about (eplerenone), I hope it can help everyone. If patients have other questions about the drug (such as drug price, purchasing channels, etc.), they can consult the medical companion travel service.

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