高血压药物依普利酮服用方法

It is a selective aldosterone receptor antagonist, has a potassium-sparing diuretic effect, can reverse left ventricular hypertrophy, lower blood pressure, and treat primary aldosteronism.  

Compared with spironolactone, eplerenone can prevent gynecomastia and sexual dysfunction, has a better potassium-sparing diuretic effect, and is mainly used clinically to treat hypertension and heart failure.  

Eplerenone reaches its peak blood concentration 1.5 hours after taking it. The half-life is about 4 to 6 hours, and its absorption is not affected by food. So how to take the high blood pressure drug eplerenone?

How to take eplerenone:

1. Congestive heart failure after acute myocardial infarction: The recommended dose is 50 mg/time, once a day. The initial dose should be 25 mg/time, once a day. Within 4 weeks, the dose should be gradually increased to 50 mg/time, once a day, as tolerated by the patient within 4 weeks.

2. Anti-hypertensive: Eplerenone can be used alone or in combination with other anti-hypertensive drugs. The recommended initial dose for use alone is 50 mg once a day. Obvious pressure-reducing effect will appear within four weeks of taking the medicine. If the pressure effect is not obvious, it can be increased to 50mg/time, twice a day. Higher dosages are not recommended, otherwise there is an increased risk of adverse reactions such as hyperkalemia.

Eplerenone also has a good antihypertensive effect on simple systolic hypertension and has a good antihypertensive effect on diet-induced obesity-related hypertension.

In addition, it can significantly reduce the ultrafiltration effect of glomeruli and reduce albuminuria in patients with hypertension. This renal protective effect is more obvious for patients with hypertension combined with diabetes.

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