高血压吃依普利酮有效果吗？

Is eating effective for high blood pressure?

Losartan was used as a reference to evaluate the clinical efficacy and safety of eplerenone in the treatment of mild to moderate essential hypertension.

Methods: 72 patients with mild to moderate hypertension were randomly divided into: ambulatory blood pressure group, losartan group, and eplerenone group, with 24 cases in each group. The losartan group and the eplerenone group used a double-simulation, positive drug parallel control method, and received losartan and eplerenone treatment respectively. After 4 weeks of treatment, if the blood pressure did not reach the target, the drug dose was doubled and the treatment continued for 4 weeks; if the blood pressure reached the target, the original dose was maintained and the treatment continued for 4 weeks. The ambulatory blood pressure group took eplerenone 25 mg once a day.

Results: After 8 weeks of treatment, compared with before treatment, the average sitting diastolic blood pressure of the eplerenone group decreased by (13.32±4.57) mmHg, and that of the losartan group decreased by (10.90±5.64) mmHg. There was no statistically significant difference between the two groups (P0.05).

After 8 weeks of treatment, the average sitting systolic blood pressure in the eplerenone group decreased compared with before treatment. (23.56±9.39) mmHg, the losartan group decreased (18.67±7.00) mmHg, and there was no statistically significant difference between the two groups (P0.05); the average of the eplerenone group and losartan group The sitting blood pressure compliance rates were 83.33% and 91.30% respectively, with no statistically significant difference between the two groups (P0.05); the antihypertensive effective rates were 75.0% and 60.9% respectively, and the total antihypertensive effective rates were respectively 91.7% and 91.3%, there was no statistically significant difference in the antihypertensive effective rate and total antihypertensive effective rate between groups (P0.05).

After 8 weeks of treatment, the blood glucose in the eplerenone group was significantly lower than before treatment (P0.05). The overall trough-to-peak ratio of systolic blood pressure in the ambulatory blood pressure group was 84.83%, and the overall trough-to-peak ratio of diastolic blood pressure was 97.56%. There was no statistically significant difference in safety indicators between the eplerenone group and losartan group before and after treatment (P0.05).

Conclusion: It can effectively and smoothly reduce blood pressure, and its safety is good.

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