依普利酮效果怎么样？

(eplerenone) is a new type of selective aldosterone receptor antagonist. In 2002, eplerenone was approved in the United States for the treatment of patients with hypertension. Eplerenone can improve the quality of life of patients with left ventricular dysfunction (ejection fraction ≤ 40%). Clinical trials have proven that eplerenone can also be used for congestive heart failure after acute myocardial infarction.

How effective is eplerenone?

In a certain study, elderly patients with systolic hypertension were treated with eplerenone (Inspra) daily (50-200) mg and amlodipine (2.5-10) mg daily. The results showed that both drugs had the same effect in lowering systolic blood pressure, while amlodipine lowered diastolic blood pressure more significantly.

After 24 weeks of treatment, the researchers found that both drugs improved carotid-femoral and carotid-radial artery pulse rates in terms of target organ protection. In terms of the incidence of adverse reactions, 19.9% ​​of the amlodipine group developed peripheral edema, while only 2.7% of the eplerenone (Inspra) group developed hyperkalemia. 0.4% of the amlodipine group developed hyperkalemia, and 0.9% of the eplerenone (Inspra) group developed hyperkalemia. In summary, eplerenone (Inspra) is effective in treating patients with hypertension and has a relatively high safety profile.

Studies have shown that for severe hypertension that cannot be controlled by a combination of multiple antihypertensive drugs, the addition of eplerenone (Inspra) can significantly reduce blood pressure, especially the decrease in systolic blood pressure is more significant. Combined treatment with angiotensin-converting enzyme inhibitors (ACEI) and beta-blockers can improve patients' quality of life and reduce mortality in severe heart failure and myocardial infarction.

The above is the introduction about (eplerenone), I hope it can help everyone. If patients have other questions about the drug (such as drug price, purchasing channels, etc.), they can consult the medical companion travel service.

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