依普利酮详细说明书

India's Lupine Pharmaceuticals is a generic drug. The following is the detailed instructions for eplerenone from India's Lupine Pharmaceuticals compiled by Medical Companion Travel:

【Indications】

1. Congestive heart failure after acute myocardial infarction: Eplerenone can improve the quality of life of patients with left ventricular dysfunction (ejection fraction ≤ 40%). Clinical trials have proven that this product can also be used for heart failure after acute myocardial infarction and congestive heart failure after acute myocardial infarction;

2. Anti-hypertensive: Eplerenone can be used alone or in combination with other anti-hypertensive drugs for the treatment of hypertension.

[Usage and Dosage] Dosage for patients with acute myocardial infarction: The starting dose is 25 mg per day. Under conditions acceptable to the patient within 4 weeks, the titrated dose will be adjusted to 50 mg per day. It should also be adjusted according to the patient's potassium level.

Hypertension: 50 mg once a day, either alone or in combination with other antihypertensive drugs. For patients with poor response, adjust to 50 mg twice a day. Higher doses are not recommended.

【Adverse reactions】

The main adverse reactions of eplerenone from Lupine Pharmaceuticals in India are: cough, diarrhea, abdominal pain, angina, myocardial infarction, proteinuria, headache, dizziness, fatigue, flu-like symptoms, etc. Other adverse reactions include: gynecomastia, abnormal vaginal bleeding; increased levels of serum potassium, triglycerides, cholesterol, alanine aminotransferase, γ-glutamyl transferase, creatinine, and uric acid, and decreased serum sodium levels.

【Notes】

(1) Lupine Pharmaceuticals of India cannot be combined with potassium supplements, potassium-containing salts or contraindicated drugs (potassium-sparing diuretics, strong inhibitors of CYP450 liver enzymes). (2) Non-steroidal anti-inflammatory drugs and lithium can affect the blood concentration of this product and affect its efficacy. (3) Patients with high serum potassium, type 2 diabetes patients with microalbuminuria, patients with high serum creatinine levels, and patients with muscle intoxication clearance <50 mL/min should not take eplerenone. (4) Pregnant women, children, and those with hepatic or renal insufficiency should use eplerenone (Inspra) with caution.

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