依普利酮在国内上市了吗？

Has India's Lupine Pharmaceuticals been launched in China? Eplerenone from India's Lupine Pharmaceuticals is only marketed in India and not domestically. Due to the influence of national conditions, eplerenone from India's Lupine Pharmaceuticals will not be launched in China. If patients need eplerenone from India's Lupine Pharmaceuticals, they can contact domestic overseas medical service institutions for consultation and purchase.

Eplerenone Indications 1. Congestive heart failure after acute myocardial infarction: Eplerenone can improve the quality of life of patients with left ventricular dysfunction (ejection fraction ≤ 40%). Clinical trials have proven that this product can also be used for congestive heart failure after acute myocardial infarction; 2. Anti-hypertension: Eplerenone can be used alone or in combination with other antihypertensive drugs for the treatment of hypertension.

The outstanding advantage of eplerenone is that it can significantly reduce blood pressure, especially systolic blood pressure, for severe hypertension that cannot be controlled by multiple antihypertensive drugs. (1) For the treatment of heart failure after acute myocardial infarction, combined use with standard treatment drugs can reduce the total mortality in the treatment group by 15% (P=0.008); (2) Eplerenone and enalapril are equally effective in reversing left ventricular hypertrophy and hypertension, with fewer cough side effects, and the combined effect is more obvious; (3) There are few adverse reactions, except for the adverse reactions of increased blood potassium, other adverse reactions are no different from the placebo group; (4) There are almost no sex hormone-related side effects of spironolactone.

Medical companions remind patients that the use of Indian Lupine Pharmaceuticals should not be combined with potassium supplements, potassium-containing salts or contraindicated drugs (potassium-sparing diuretics, strong inhibitors of CYP450 liver enzymes). At the same time, non-steroidal anti-inflammatory drugs and lithium can affect the blood concentration of eplerenone and affect its efficacy, so these drugs cannot be taken at the same time.

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