希爱力(Tadalafil)的功效与作用

Cialis (Tadalafil) is a phosphodiesterase 5 (PDE5) inhibitor. Since it was first approved in the United States in 2003, it has become an important drug for the treatment of erectile dysfunction (ED), benign prostatic hyperplasia (BPH), and their dual symptoms.

Efficacy and effects of Cialis (Tadalafil)

The main mechanism of action is to increase the concentration of cyclic guanosine monophosphate (cGMP) by inhibiting the PDE5 enzyme, thereby relaxing smooth muscles and promoting blood vessel dilation.

Under sexual stimulation, nitric oxide (NO) is released, activating guanylyl cyclase, causing the level of cGMP to increase, thereby promoting congestion of the corpus cavernosum of the penis to achieve and maintain an erection.

In addition, Cialis also has a similar effect on the smooth muscles of the prostate and bladder, which can relieve urinary tract symptoms caused by BPH.

Cialis works only in the presence of sexual stimulation and does not automatically cause an erection. This mechanism makes it excellent in terms of security and targeting.

The pictures come from public channels (such as the official website of the FDA, the official website of the original drug manufacturer, etc.) and are for reference only.

Indications of Cialis (Tadalafil)

1. Treatment of erectile dysfunction (ED)

Erectile dysfunction is a common sexual health problem in men, characterized by the inability to achieve or maintain an adequate erection to complete a satisfactory sexual life. Cialis significantly improves erectile function by increasing blood flow to the penis.

Clinical studies show that after taking Cialis, most patients can take effect within 30 minutes, and the effect can last up to 36 hours, providing patients with a more natural sexual life time choice.

2. Relieve the symptoms of benign prostatic hyperplasia (BPH)

BPH is a common urinary system disease in middle-aged and elderly men, which is characterized by symptoms such as frequent urination, urgency, increased nocturia, and weakened urine flow. Cialis relaxes the smooth muscles of the prostate and bladder neck and improves urodynamics, thereby reducing obstructive and irritative symptoms.

Taking 5mg of Cialis once a day can significantly improve the patient's quality of life.

3. Treat ED and BPH at the same time

For men who have both ED and BPH, Cialis provides a treatment plan that kills two birds with one stone. A once-daily dose of 5 mg can improve erectile function and relieve urinary symptoms, avoiding the complexity of multiple medications.

Usage and dosage of Cialis (Tadalafil)

1. Take it as needed (for ED)

Most patients are recommended to start with 10mg and take it 30 minutes before expected sexual intercourse, up to once a day. The dose may be adjusted to 5 mg or 20 mg based on individual response and tolerability. It is recommended to take it under sexual stimulation, otherwise it may not be effective.

2. Once a day (for BPH or ED/BPH)

Take 5mg at a fixed time every day, no need to consider the time of sexual intercourse. This usage is suitable for patients who require sustained relief from BPH symptoms or who wish to maintain erectile function at all times.

3. Dose adjustment for special groups

(1) Patients with renal insufficiency: The dose needs to be adjusted based on creatinine clearance. For patients with severe renal insufficiency, it is recommended to take it once every 72 hours.

(2) Patients with hepatic insufficiency: Mild to moderate patients can take 10mg, but severe patients are not recommended.

(3) Elderly people: Usually there is no need to adjust the dosage, but adverse reactions should be carefully monitored.

Contraindications and important warnings about Cialis (Tadalafil)

1. Absolute contraindications

(1) Combination with any form of nitrate drugs (such as nitroglycerin, isosorbide mononitrate) may cause a sudden drop in blood pressure and be life-threatening.

(2) Those who are allergic to Cialis or any of its ingredients.

(3), combined with guanylyl cyclase stimulators (such as riociguat).

2. Cardiovascular risk

Sexual activity puts a certain load on the heart, so patients with cardiovascular diseases (such as angina, heart failure, recent myocardial infarction) should use it after a doctor's evaluation. If symptoms such as chest pain and dizziness occur during sexual intercourse, stop immediately and seek medical advice.

3. Risk of hypotension

Combined use with alpha-blockers, antihypertensive drugs or large amounts of alcohol may increase the risk of hypotension.

4. Sustained erection (Priapism)

If the erection lasts for more than 4 hours, you need to seek medical attention immediately, otherwise permanent damage may occur.

5. Vision and hearing problems

A very small number of patients may experience sudden vision or hearing loss and need to stop taking the drug and seek medical treatment.

Common and rare adverse reactions of Cialis (Tadalafil)

Cialis is generally well tolerated. Common adverse reactions include headache, indigestion, back pain, muscle aches, nasal congestion, facial flushing, and limb pain. These symptoms are mostly mild to moderate and usually resolve on their own within a few hours.

Rare but serious adverse reactions include persistent erection, sudden loss of vision (NAION), sudden hearing loss, allergic reactions (such as Stevens-Johnson syndrome), etc. Patients should be aware of these potential risks and seek prompt medical attention if abnormalities occur.